【生物医学工程高精尖创新中心】美国德克萨斯大学奥斯丁分校姜宁教授Professor. Ning JIANG学术报告通知-北航医工交叉创新研究院
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【生物医学工程高精尖创新中心】美国德克萨斯大学奥斯丁分校姜宁教授Professor. Ning JIANG学术报告通知

发布时间:2018-07-13 13:06   点击次数:

报告题目High-throughput T cell repertoire profiling enabled systems immunology and immune  engineering

报告人:姜宁,美国德克萨斯大学奥斯汀分校,副教授

报告时间7月18日(星期三)下午4:30

报告地点:逸夫科学馆317会议室

邀请人:北航生物医学工程高精尖创新中心

报告摘要Recent technological advancement have enabled high-throughput measurement of immune receptor sequence repertoire as well as characterizing of T cell phenotype and function at single cell level. However, how to evaluate T cell receptor binding affinity in a high-throughput fashion and decipher the interaction between the ligand repertoire and T cell receptor repertoire are still challenging. In this talk, I will first introduce three different technologies that my lab developed, an ultra-accurate immune repertoire sequencing, a high-throughput TCR affinity measurement, and a high-throughput linking of antigen specificity to T cell receptor sequences. Then, I will give examples on    how to use them to study antibody repertoire development and its response to malaria infection in infants and profile T cell repertoire for cancer immunotherapy.

报告人简介Dr. Jiang is an associate professor in the Department of Biomedical Engineering at    the University of Texas at Austin. She obtained her Ph.D. from Georgia Institute of Technology      where she developed a tool to measure T cell receptor affinity on T cell membrane and used it to     study molecular mechanisms of T cell receptor antigenic ligand discrimination. Before joining the   faculty at UT Austin in January 2012, she was a postdoctoral fellow in Dr. Stephen Quake’s lab at  Stanford University where she developed the first generation of high-throughput immune repertoire sequencing   technology. Her lab at UT Austin focuses on systems immunology by developing technologies that  enable the direct profiling of human immune systems in cancer and vaccination. These technologies  include a 2nd generation of immune repertoire sequencing technology that increase the accuracy 150 times, a high-throughput T cell receptor affinity and sequence test, and a high-throughput tool to  link antigen specificity to T cell receptor sequences. Dr. Jiang is the recipient of the prestigious NIH Pathway to Independence Award (K99/R00), Cancer Prevention and Research Institute of Texas, Damon Runyon-Rachleff Innovator Award, and NSF CAREER Award.