长期致力于研究生物组织及其标志物的无标记定量成像,围绕成像速度、生物标志物、模态通用性三大核心瓶颈开展研究,取得了一系列成果,在国际权威期刊Nature Commun.、Light: Science & Applications、IEEE Transactions on Image Processing等发表SCI论文20余篇。1)成像速度方面,提出基于半色调二值编码和深度学习的空间频域成像新方法,在相同硬件条件下,将空间频域成像的数据采集速度和数据处理速度分别最高提高了2个数量级和5个数量级,研究成果发表在Light:Science & Applications、Optics Letters等期刊;2)生物标志物方面,研究解决了空间频域成像在短波红外波段仪器标定的关键技术瓶颈,定量解耦了扩散光在短波红外波段的吸收与散射效应,研制了可对组织中水和脂肪成分进行无标记非侵入高分辨定量成像的短波红外空间频域成像仪,将生物组织中可无创无标记高分辨定量测量的生物标志物种类从血红蛋白扩展至水和脂质,研究成果发表在Nature Communications;3)模态通用性方面,研究提出抗散射智能算法与成像系统,将光场调控速度提高2个数量级,将光声层析成像所需探测器数量降低2-3个数量级,成果发表在Light:Science & Applications、Photoacoustics等期刊。
[1] Yanyu Zhao, Anahita Pilvar, Anup Tank, Hannah Peterson, John Jiang, Jon C. Aster, John Paul Dumas, Mark C. Pierce, and Darren Roblyer. "Shortwave-infrared meso-patterned imaging enables label-free mapping of tissue water and lipid content", Nature Communications 11, 1 (2020).
[2] Yanyu Zhao#, Bowen Song, Ming Wang, Yang Zhao, Yubo Fan#, "Halftone spatial frequency domain imaging enables kilohertz high-speed label-free non-contact quantitative mapping of optical properties for strongly turbid media", Light: Science & Applications, 10, 245 (2021).
[3] Jiamiao Yang, Qiaozhi He, Linxian Liu#, Yuan Qu, Rongjun Shao, Bowen Song, Yanyu Zhao#, "Anti-scattering light focusing by fast wavefront shaping based on multi-pixel encoded digital-micromirror device", Light: Science & Applications, 10, 149 (2021).
[4] Bingbao Yan, Bowen Song, Chang Ge, Xinman Yin, Wenchao Jia, Gen Mu, Yanyu Zhao#, "Deep Ensemble Model for Quantitative Optical Property and Chromophore Concentration Images of Biological Tissues", IEEE Transactions on Image Processing, 34, 4999-5008 (2025).
[5] Bingbao Yan, Bowen Song, Gen Mu, Yubo Fan#, Yanyu Zhao#, "Compressed single-shot 3D photoacoustic imaging with a single-element transducer", Photoacoustics, 34, 100570 (2023).