【生物医学工程高精尖中心】法国索邦大学Pascal LAUGIER教授学术报告通知

Bone mechanical properties which fascinates not only scientists but also engineers are the results of the highly hierarchized and organized structure and the compositional properties spanning over several lengths from the nanoscale to the macroscale. Deep understanding of parameters affecting bone mechanical  behavior is necessary to better predict and treat bone diseases, improve orthopedic implants design, and engineer bio-inspired materials. Resonant ultrasound spectroscopy is a powerful method to investigate   bone stiffness at different scales. In this work, a special focus is placed on human cortical bone elastic     properties both at the millimeter and micrometer scales.

 

Based on a multimodal approach (resonant ultrasound spectroscopy, synchrotron radiation micro-computed tomography, Fourier transform infrared micro-spectroscopy and biochemistry experiments), our results provide strong evidence that intra-cortical porosity and degree of mineralization are the most    important determinants of bone stiffness at millimeter scale in an elderly population. Microstructural     characteristics independent of porosity have non-measurable effects on bone stiffness at this level. At the micrometer scale, a novel inverse homogenization approach is introduced which can evaluate bone matrix anisotropic elastic properties with a good accuracy for all the stiffness constants.