王柯皓 副教授/博士/博士生导师/医工百人
医学科学与工程学院/北京航空航天大学
医工交叉创新研究院/北京市生物医学工程高精尖创新中心
北航教师个人主页:http://shi.buaa.edu.cn/kehaowang/zh_CN/index.htm
电子邮箱:kehaowang@buaa.edu.cn
【教育背景】
2014.10-2017.09 英国金斯顿大学 | 生物医学工程 | 博士学位(导师:Barbara K. Pierscionek)
2013.09-2014.09 英国伦敦大学学院 | 医学物理与工程 | 硕士学位(导师:Terence S. Leung)
2009.09-2013.07 天津大学 | 生物医学工程 | 工学学士学位
2012.09-2013.05 英国邓迪大学 | 机械工程 | 3+1中英交流项目(导师:George Corner)
【工作经历】
2022.01-至今 北京航空航天大学 | 医学科学与工程学院 | 副教授
2020.06-2021.12 北京航空航天大学 | 医工交叉创新研究院 | 副研究员
2017.05-2020.06 英国诺丁汉特伦特大学 | 科学与技术学院 | 博士后(合作导师:Barbara K. Pierscionek)
【研究领域】
主要研究方向聚焦于眼生物力学、生理光学及眼组织工程学,侧重老花眼、视调节理论、白内障可逆性研究以及眼科微创植介入器械设计。
广泛运用生物力学测量、有限元分析及生理系统建模、光学及同步辐射成像等多种技术探究医工交叉领域的前沿问题。
【代表性科研项目】
1.国家自然科学基金面上项目,视调节及老视发展过程中悬韧带对晶状体的力作用机制研究,2024.01-2027.12,在研,主持。
2.国家重点研发计划子课题,面向视障人群的视功能评估、助视补偿和代偿、康复训练技术的研究及相关产品研发与应用,2023.12-2026.11,在研,主持。
3.国家自然科学基金青年基金,眼晶状体力学弹性与光学屈光力的关联分析,2021.01-2023.12,结题,主持。
4.北京航空航天大学 “青年拔尖” 项目,眼晶状体光学及力学特性研究,2021.01-2025.12,在研,主持。
5.日本国立同步辐射中心(JASRI)课题研究项目,2018.06-至今,眼晶状体的进化、多物种晶体的生长发育及白内障可逆性研究,96机时/年,在研,执行负责人。
6.卡尔蔡司(Carl Zeiss Meditec)合作项目,Design and Modelling of Accommodating Intraocular Lens,2017.05-2020.06,结题,执行负责人。
【代表性论著】
[1] Kehao Wang; Yutian Pu; Leran Chen; Masato Hoshino; Kentaro Uesugi; Naoto Yagi; Xiaoyong Chen; Yuu Usui; Akira Hanashima; Ken Hashimoto; Satoshi Mohri; Barbara K Pierscionek. Optical development in the murine eye lens of accelerated senescence-prone SAMP8 and senescence-resistant SAMR1 strains, Experimental Eye Research, 2024, 241(9459);109858.
[2] Kehao Wang; Yunxin Xia; Xiaofei Wang; Yutian Pu; Yune Zhao; Pingjun Chang; Barbara K. Pierscionek; Yubo Fan. Influence of design parameters and capsulorhexis on intraocular lensstabilities: A 3D finite element analysis, Computers in Biology and Medicine, 2023, 160:
106972. (中科院TOP期刊)
[3] Yutian Pu; Ziyuan Liu; Lin Ye; Yunxin Xia; Xiaoyong Chen; Kehao Wang*; Barbara K.
Pierscionek ; The major influence of anterior and equatorial zonular fibres on the far-to-near
accommodation revealed by a 3D pre-stressed model of the anterior eye, Computer Methods and Programs in Biomedicine, 2023, 242: 107815. (中科院TOP期刊)
[4] Kehao Wang; Ziyan Qiu; Yiping Xie; Shuo Cai; Yang Zhao; Barbara K. Pierscionek; Jiangzhen Guo; Yubo Fan ; Design of an Automatically Controlled Multi-Axis Stretching Device for Mechanical Evaluations of the Anterior Eye Segment, Bioengineering, 2023, 10(2): 142.
[5] Kehao Wang; Masato Hoshino; Kentaro Uesugi; Naoto Yagi; Barbara K Pierscionek; Usha P Andley ; Oxysterol Compounds in Mouse Mutant αA- and αB-Crystallin Lenses Can Improve the Optical Properties of the Lens, Investigative Ophthalmology& Visual Science, 2022, 63(5):15. (中科院TOP期刊)
[6] Kehao Wang; Irene Vorontsova; Masato Hoshino; Kentaro Uesugi; Naoto Yagi; James Ewbank Hall; Thomas Friedrich Schilling; Barbara Krystyna Pierscionek ; Aquaporins Have Regional Functions in Development of Refractive Index in the Zebrafish Eye Lens, Investigative Ophthalmology & Visual Science, 2021, 62(3): 23. (中科院TOP期刊)
[7] Kehao Wang; Masato Hoshino; Kentaro Uesugi; Naoto Yagi; Robert D. Young; Bethany E. Frost; Justyn W. Regini; Andrew J. Quantock; Barbara K. Pierscionek ; Cell compaction is not required for the development of gradient refractive index profiles in the embryonic chick lens, Experimental Eye Research, 2020, 197: 108112 (Q1)
[8] Kehao Wang; Irene Vorontsova; Masato Hoshino; Kentaro Uesugi; Naoto Yagi; James E. Hall; Thomas F. Schilling; Barbara K. Pierscionek ; Optical development in the zebrafish eye lens, The FASEB Journal, 2020, 34(4): 5552-5562 (中科院TOP期刊)
[9] Wang, Shuangy#i; Wang, Kehao#; Tang, Ruijie; Qiao, Jingzhe; Liu, Hongbin; Hou, Zeng-Guang; Design of a Low-Cost Miniature Robot to Assist the COVID-19 Nasopharyngeal Swab Sampling, IEEE Transactions on Medical Robotics and Bionics, 2021, 3(1): 289-293.
[10] Kehao Wang; Barbara K Pierscionek ; Biomechanics of the human lens and accommodative system: Functional relevance to physiological states, Progress in Retinal and Eye Research, 2019, 71: 114-131 (中科院TOP期刊)
[11] Kehao Wang; Demetrios T Venetsanos; Masato Hoshino; Kentaro Uesugi; Naoto Yagi; Barbara K Pierscionek ; A modeling approach for investigating opto-mechanical relationships in the human eye lens, IEEE Transactions on Biomedical Engineering, 2020, 67(4): 999-1006
[12] Kehao Wang; Masato Hoshino; Kentaro Uesugi; Naoto Yagi; Barbara K. Pierscionek ;
Contributions of shape and stiffness to accommodative loss in the ageing human lens: a finite
element model assessment, Journal of the Optical Society of America A, 2019, 36(4): B116-
B122.
[13] Kehao Wang; Demetrios T Venetsanos; Jian Wang; Andy T. Augousti; Barbara K. Pierscionek ; The importance of parameter choice in modelling dynamics of the eye lens, Scientific Reports, 2017, 7: 16688 (Q1)
[14] Kehao, Wang; Demetrios, Venetsanos; Jian, Wang; Barbara K., Pierscionek ; Gradient moduli lens models: how material properties and application of forces can affect deformation and distributions of stress, Scientific Reports, 2016, 6(1): 31171 (Q1)