陈珣,助理教授
医学科学与工程学院
北航教师个人主页:https://shi.buaa.edu.cn/chenxun/zh_CN/
电子邮箱:chenxun2007@buaa.edu.cn
【教育背景】
2007.09-2011.07,天津大学,生物医学工程系,本科
2011.09-2014.07,天津大学,生物医学工程系,硕士研究生
2015.01-2019.12,美国克莱姆森大学,生物工程系,博士研究生
【工作经历】
2020.03-2021.12,北京航空航天大学,生物与医学工程学院,博士后
2022.1-至今,北京航空航天大学,医学科学与工程学院,助理教授
【研究领域】
医用光子学、无标记分子成像、光学内窥镜、智能医学图像处理
1无标记分子成像
NADH/FAD分子自荧光成像用于细胞存活率研究;
脂质、蛋白、DNA分子相干拉曼散射成像用于肿瘤精准诊断;
2光学内窥镜
共聚焦消化内窥镜用于癌前病变筛查、肿瘤精准诊断;
自发拉曼、OCT内窥镜用于术中无创切缘检测;
【代表性科研项目】
(1) 北京市自然科学基金,青年项目,可无创动态监测软组织细胞的在体双光子自荧光内窥镜, 主持。
(2) 北京市自然科学基金,小米联合基金前沿项目,连续高精度的手持式相干拉曼无创血糖测量仪,主持。
(3) 北京航空航天大学,青年拔尖人才计划,基于拉曼光谱的内窥镜技术研究,主持。
(4) 中国博士后科学基金,面上项目,非线性光学微型关节镜在关节软骨移植中的应用,主持。
(5) 国家自然科学基金,国家重大科研仪器项目,可无创实时动态监测循环肿瘤细胞的多模态在体流式图像细胞仪,参与。
【代表性论著】
(1) Chen, P#., Chen, X.#, Hepfer, R.G., Damon, B.J., Shi, C., Yao, J.J., Coombs, M.C., Kern, M.J., Ye, T. and Yao, H., 2021. A noninvasive fluorescence imaging-based platform measures 3D anisotropic extracellular diffusion. Nature communications, 2021, 12(1), pp.1-17.
(2) Chen, X., Li, Y., Wyman, N., Zhang, Z., Fan, H., Le, M., Gannon, S., Rose, C., Zhang, Z., Mercuri, J. and Yao, H., Deep learning provides high accuracy in automated chondrocyte viability assessment in articular cartilage using nonlinear optical microscopy. Biomedical Optics Express, 2021, 12(5), pp.2759-2772.
(3) Chen, X.; Cui, Sishan; Yan, Shuai;Zhang, Shuo; Fan, Yu; Gong,Yanqing; Zhou, Liqun; Wang, Ping;Yao, Lin; Yue, Shuhua, Hyperspectral stimulated Raman scattering microscopy facilitates differentiation of low-grade and high-grade human prostate cancer. Journal of Physics D Applied Physics, 2021, 54 (48), pp. 484001.
(4) Yang, Xuefang, Wang, Ye, Zhang, Hejun, Qin, Haoye, Wang, Siyu, Tong, Yihang, Zhou, Keji,Sun, Rui, Yue, Shuhua*, Chen, X. *, Ding,Shigang*, Wang,Pu*, Fiber-optic large-depth 3D chromatic confocal endomicroscopy, Biomedical Optics Express, 2022, 13(1): 300-313.
(5) Sun, Bo, Wang, Zhaoyi,Lin, Jiaqian, Chen, Chen, Zheng, Guanghui, Yue, Shuhua, Wang, Haiquan, Kang, Xixiong*, Chen, X.*, Hong, Weili*, Wang,Pu*, Automatic quantitative analysis of metabolism inactivation concentration in single bacterium using stimulated Raman scattering microscopy with deep learning image segmentation, Medicine in Novel Technology and Devices, 2022, 14:0-100114.
(6) Chen, X., Feng, Y., Lu, J.Q., Liang, X., Ding, J., Du, Y. and Hu, X.H., Fast method for inverse determination of optical parameters from two measured signals. Optics letters, 2013, 38(12), pp.2095-2097.
(7) Richards, D.J., Li, Y., Kerr, C.M., Yao, J., Beeson, G.C., Coyle, R.C., Chen, X., Jia, J., Damon, B., Wilson, R. and Hazard, E.S., Human cardiac organoids for the modelling of myocardial infarction and drug cardiotoxicity. Nature biomedical engineering, 2020, 4(4), pp.446-462.
(8) Yan, W., Yang, Y., Tan, Y., Chen, X., Li, Y., Qu, J. and Ye, T., Coherent optical adaptive technique improves the spatial resolution of STED microscopy in thick samples. Photonics research, 2017, 5(3), pp.176-181.
(9) Li, Y., Chen, X., Watkins, B., Saini, N., Gannon, S., Nadeau, E., Reeves, R., Gao, B., Pelligrini, V., Yao, H. and Mercuri, J., Nonlabeling and quantitative assessment of chondrocyte viability in articular cartilage with intrinsic nonlinear optical signatures. Experimental Biology and Medicine, 2020, 245(4), pp.348-359.
(10) Tian, P., Chen, X., Jin, J., Lu, J.Q., Liang, X. and Hu, X.H., Stochastic model for quantifying effect of surface roughness on light reflection by diffuse reflectance standards. Optical Engineering, 2018, 57(9), p.094104.