张靖 教授
医学科学与工程学院 医工交叉创新研究院 生物医学工程高精尖创新中心
北航教师个人主页：http://shi.buaa.edu.cn/jz2716/zh_CN/index.htm
电子邮箱：jz2716@buaa.edu.cn
【教育背景】
[1] 2005.9-2009.6 中国科学院自动化研究所 | 控制科学与工程 | 博士学位 | 博士研究生毕业
[2] 2002.9-2005.6 哈尔滨理工大学 | 计算机科学与技术 | 硕士学位 | 硕士研究生毕业
[3] 1998.9-2002.6 哈尔滨理工大学 | 控制科学与工程 | 学士学位 | 大学本科毕业
【工作经历】
[1] 2019.6-至今 北京航空航天大学 | 教授
[2] 2015.7-2019.6 Columbia University | Associate Research Scientist
[3] 2014.1-2015.6 中国科学院北京基因组研究所 | 副研究员
[4] 2009.7-2013.12 中国科学院北京基因组研究所 | 助理研究员
【研究领域】
[1] 深度学习方法开发，以解决肿瘤发生发展，预后，免疫相关科学问题
集中在开发深度学习(Deep Learning)模型和方法，特别是概率模型和新颖的推断方法，通过新的深度学习方法学习实体肿瘤多组学数据的内在规律和表示层次，解决肿瘤发生发展，预后，免疫相关的科学问题。
[2] 机器学习方法应用，研究免疫系统与肿瘤发生发展之间的交互作用关系
机器学习（Machine Learning）是人工智能技术的核心，主要集中在开展各种机器学习方法的应用，通过挖掘多组学数据研究免疫系统如何与肿瘤细胞之间相互作用，开发出能杀死肿瘤细胞的疫苗。
[3] 机器学习方法开发，开发针对肿瘤和病毒的多肽疫苗
新的机器学习方法的开发，主要集中在开发新的机器学习方法，从高通量组学数据中进行特征提取与模式识别，鉴定具有高质量免疫原性的肿瘤疫苗、病毒疫苗等，并进行体外、动物实验，开发疫苗，防止重大疾病和传染病的产生。
[4] 转基因动物模型构建， 从分子生物学的机制层面研究肿瘤免疫、多肽疫苗相关的科学问题构建转基因动物模型，在活体动物上验证大规模计算发现。
[5] 生物医学诊疗平台的开发
开发生物医学诊疗平台，实现人工智能个性化治疗。
【代表性论著】
[1] Jing Li, Zhongpeng Zhao, Chengzheng Tai, Ting Sun, Lingyu Tan, Xinyu Li, Wei He, Hongjun Li#, Jing Zhang#. VirusImmu: a novel ensemble machine learning approach for viral immunogenicity prediction. Briefings in functional genomics,2025, Jan, 24:elaf008. (#通讯作者，发表时影响因子：2.5)
[2] Yunsong Liu, Yi Wang, Xinyang Hu, Xin Wang, Liyan Xue, Qingsong Pang, Huan Zhang, Zeliang Ma, Heping Deng, Zhaoyang Yang, Xujie Sun, Yu Men, Feng Ye, Kuo Men, Jianjun Qin, Nan Bi, Jing Zhang#, Qifeng Wang#, Zhouguang Hui#. Multimodality deep learning radiomics predicts pathological response after neoadjuvant chemoradiotherapy for esophageal squamous cell carcinoma. Insights into Imaging, 2024, Nov, 15(1):277. (#通讯作者，发表时影响因子：4.1)
[3] Jing Na, Chengzheng Tai, Ziyi Wang, Zhijie Yang, Xinyuan Chen, Jing Zhang#, Lisha Zheng#, Yubo Fan#. Stiff extracellular matrix drives the differentiation of mesenchymal stem cells toward osteogenesis by the multiscale 3D genome reorganization. Biomaterials,2024, Jul, 312:122715. (#通讯作者，发表时影响因子：12.8)
[4] Ting Sun, Junge Chen, Fan Yang, Gang Zhang, Jiahao Chen, Xun Wang#, Jing Zhang#. Lipidomics reveals new lipid-based lung adenocarcinoma early diagnosis model. EMBO Molecular Medicine, 2024, Apr, 16(4):854-869. (#通讯作者，发表时影响因子：11.1)
[5] Lu Wang, Zhiyuan Xu, Wei Zhang, Lin Li, Xiao Liu, Jing Zhang#. Comprehensive characterization and database construction of immune repertoire in the largest Chinese glioma cohort. iScience, 2024 Jan,27(1):108661(#通讯作者，发表时影响因子：5.8)
[6] Chengzheng Tai, Hongjun Li#, Jing Zhang#.BCEDB: a linear B-cell epitopes database for SARS-CoV-2. Database-The Journal of Biological Databases and Curation,2023 Sep,baad065. (#通讯作者，发表时影响因子：5.8)
[7] Lin Li, Zhongpeng Zhao, Xiaolan Yang, Zhongyi Su, Wendong Li, Shaolong Chen, Lu Wang, Ting Sun, Chen Du, Ziyi Li, Zeqian Yang, Min Li, Tiecheng Wang, Ying Wang#, Yubo Fan#, Hui Wang#, Jing Zhang#. A newly identified Spike protein targeted linear B-cell epitope based dissolvable microneedle array successfully eliciting neutralizing activities against SARS-CoV-2 wild-type strain in mice. Advanced Science, 2023 May;e2207474. (#通讯作者，发表时影响因子：17.5)
[8] Ting Sun, Yuchen Wang, Xiaoyu Song, Ruili Li, Fanghua Mei, Mengliu Yang, Xiaojie Huang, Yan Li, Xuwei Zhou, Haoyu Wang, Wendong Li, Jing Li, Lu Wang, Wei Shi#, Kun Cai#, Hongjun Li#, Jing Zhang#. Inactivated SARS-CoV-2 vaccine recipients without anti-Spike RBD antibodies. Microbiology Spectrum, 2023, Mar; e0278322. (#通讯作者，发表时影响因子：9.043)
[9] Qiao Zhang, Qingzhu Jia, Jing Zhang#, Bo Zhu#. Neoantigens in precision cancer immunotherapy: from identification to clinical applications. Chin Med J (Engl), 2022, Jun;135(11):1285-1298. (#通讯作者，发表时影响因子：6.1)
[10] Guanzhang Li*, Lin Li*, Yiming Li, Zenghui Qian, Fan Wu, Yufei He, Haoyu Jiang, Renpeng Li, Di Wang, You Zhai, Zhiliang Wang, Tao Jiang, Jing Zhang#, Wei Zhang#. An MRI radiomics approach to predict survival and tumour-infilitrating macrophages in gliomas. Brain,2022, Mar; 145(3):1151-1161. (#通讯作者，发表时影响因子：13.5，高被引论文)
[11] Wendong Li*, Ting Sun*, Muyang Li, Yufei He, Lin Li, Lu Wang, Haoyu Wang, Jing Li, Hao Wen, Yong Liu, Yifan Chen, Yubo Fan#, Beibei Xin#, Jing Zhang#. GNIFdb: a neoantigen intrinsic feature database for glioma. Database-The Journal of Biological Databases and Curation, 2022 Feb, baac0. (#通讯作者，发表时影响因子：3.451)
[12] Zixuan Xiao*, Wei Zhang*, Guanzhang Li*, Wendong Li, Lin Li, Ting Sun, Yufei He, Guang Liu, Lu Wang, Xiaohan Han, Hao Wen, Yong Liu, Yifan Chen, Haoyu Wang, Jing Li, Yubo Fan#, Jing Zhang#. Multiomics analysis reveals the prognostic non-tumour cell landscape in glioblastoma niches. Frontiers in Genetics, 2021 Sep;12:741325. (#通讯作者，发表时影响因子：4.599)
[13] Ting Sun*, Yufei He*, Wendong Li*, Guang Liu, Lin Li, Lu Wang, Zixuan Xiao, Xiaohan Han, Hao Wen, Yong Liu, Yifan Chen, Haoyu Wang, Jing Li, Yubo Fan#, Wei Zhang#, Jing Zhang#. neoDL: a novel neoantigen intrinsic feature-based deep learning model identifies IDH wild-type glioblastomas with the longest survival. BMC Bioinformatics, 2021 Jul, 22(1):382. (#通讯作者，发表时影响因子：3.169)
[14] Wendong Li, Lin Li, Ting Sun, Yufei He, Guang Liu, Zixuan Xiao, Yubo Fan#, Jing Zhang#. Spike protein-based epitopes predicted against SARS-CoV-2 through literature mining. Medicine in Novel Technology and Devices. 2020 Dec;8:100048. （#通讯作者）
[15] Lin Li, Ting Sun, Yufei He, Wendong Li, Yubo Fan#, Jing Zhang#. Epitope-based peptide vaccines predicted against novel coronavirus disease caused by SARS-CoV-2. Virus Research, 2020 Oct;288:198082. (#通讯作者，发表时影响因子：2.934)
[16] Qixue Wang*, Jinquan Cai*, Chuan Fang, Chao Yang, Junhu Zhou, Yanli Tan, Yunfei Wang, Yansheng Li, Xiangqi Meng, Kai Zhao, Kaikai Yi, Sijing Zhang, Jianning Zhang, Chuanlu Jiang#, Jing Zhang#, Chunsheng Kang#. Mesenchymal glioblastoma constitutes a major ceRNA signature in the TGF-β pathway. Theranostics, 2018 Sep, 8(17):4733-4749. (#通讯作者)
[17] Dong Zou, Shixiang Sun, Rujiao Li, Jiang Liu, Jing Zhang# and Zhang Zhang#. MethBank: a database integrating next-generation sequencing single-base-resolution DNA methylation programming data. Nucleic Acids Research, 2015 Jan;43(Database issue):D54-58. (#通讯作者)
[18] Xiaocui Xu*, Guoqiang Li*, Congru Li*, Jing Zhang*, Qiang Wang*, David K Simmons, Xuepeng Chen, Naveen Wijesena, Wei Zhu, Zhanyang Wang, Zhenhua Wang, Bao Ju, Weimin Ci, Xuemei Lu, Daqi Yu, Qian-fei Wang, Neelakanteswar Aluru, Paola Oliveri, Yong E Zhang, Mark Q Martindale, Jiang Liu. Evolutionary transition between invertebrates and vertebrates via methylation reprogramming in embryogenesis. National Science Review, 2019 May, nwz064. (*共同第一)
[19] Jing Zhang, Francesca P. Caruso, Jason K. Sa, Sune Justesen, Do-Hyun Nam, Peter Sims, Michele Ceccarelli, Anna Lasorella, Antonio Iavarone. The combination of neoantigen quality and T lymphocyte infiltrates identifies glioblastomas with the longest survival. Communications Biology, 2019 Apr, 2:135. (第一)
[20] Ke Chen*, Jing Zhang*, Zhongqiang Guo*, Qin Ma, Zhengzheng Xu, Yuanyuan Zhou, Zhiying Xu, Zhongwu Li, Yiqiang Liu, Xiongjun Ye, Xuesong Li, Bifeng Yuan, Yuwen Ke, Chuan He, Liqun Zhou, Jiang Liu, Weimin Ci. Loss of 5-hydroxymethylcytosine is linked to gene body hypermethylation in kidney cancer. Cell Research, 2016 Jan; 26(1):103-118. (*共同第一)
[21] Lan Jiang*, Jing Zhang*, Jing-Jing Wang*, Lu Wang, Li Zhang, Guoqiang Li, Xiaodan Yang, Xin Ma, Xin Sun, Jun Cai, Jun Zhang, Xingxu Huang, Miao Yu, Xuegeng Wang, Feng Liu, Chung-I Wu, Chuan He, Bo Zhang, Weimin Ci, Jiang Liu. Sperm, but not oocyte, DNA methylome is inherited by zebrafish early embryos. Cell, 2013 May; 153(4):773-84. (*共同第一)
[22] Junxia Zhang*, Jing Zhang*, Wei Yan*, Yingyi Wang*, Lei Han, Anling Zhang, Xiao Yue, Ning Liu, Yongying You, Tao Jiang, Peiyu Pu, Chunsheng Kang. Unique genome-wide map of TCF4 and STAT3 targets using ChIP-seq reveals their association with new molecular subtypes of glioblastoma. Neuro-Oncology, 2013 March; 15(3):279-89. (*共同第一）
[23] Wei Zhang*, Jing Zhang*, Wei Yan, Gan You, Zhaoshi Bao, Shouwei Li, Chunsheng Kang, Chuanlu Jiang, Yongping You, Yuxiang Zhang, Clark C. Chen, Sonya Wei Song, Tao Jiang. Whole-genome microRNA expression profiling identifies a 5-microRNA signature as a prognostic biomarker in Chinese patients with primary glioblastoma multiforme. Canceer-AM Cancer Soc, 2013 February; 119(4):814-824. (*共同第一）
[24] Yuchen Li*, Tao Jiang*, Jing Zhang*, Bin Zhang, Wei Yang, Gan You, Kaiyu Xu, Jing Wu, Chenghua Luo, Sonya W Song. Elevated serum antibodies against insulin-like growth factor-binding protein-2 allow detecting early stage cancers: evidences from glioma and colorectal carcinoma studies. Annals of Oncology, 2012 September; 23(9):2415-2422. (*共同第一）
[25] Wei Zhang*, Jing Zhang*, Katherine Hoadley, Deepa Kushwaha, Valya Ramakrishnan, Shouwei Li, Chunsheng Kang, Yongping You, Chuanlu Jiang, Songya Wei Song, Tao Jiang, Clark C. Chen. miR-181d: a predictive glioblastoma biomarker that down regulates MGMT expression. Neuro-Oncology, 2012 June; 14(6):712-719. (*共同第一）
[26] Jing Zhang, Bing Liu, Xingpeng Jiang, Huizhi Zhao, Ming Fan, Zhenjie Fan, J. Jack Lee, Tao Jiang, Tianzi Jiang, Sonya W Song. A systems biology-based gene expression classifier of glioblastoma predicts survival with solid tumors. PLoS ONE, 2009 July; 4(7):e6274. (第一)
[27] Jing Zhang, Tianzi Jiang, Bing Liu, Xingpeng Jiang, Huizhi Zhao. Systematic benchmarking of microarray data feature extraction and classification. International Journal of Computer Mathematics, 2008 May; 85(5):803-811. (第一)
