曹芳芳 教授、国家级青年人才
医学科学与工程学院
北航教师个人主页：https://shi.buaa.edu.cn/caofangfang/zh_CN/index.htm
电子邮箱：fangfangcao@buaa.edu.cn
【教育背景】
2014-2019 长春应化所 无机化学 博士 导师：任劲松 研究员 & 曲晓刚 研究员
2010-2014 南京师范大学 化学 学士
【工作经历】
2025-至今 北京航空航天大学 医学科学与工程学院 教授
2021-2025 新加坡国立大学 杨潞龄医学院 博士后 导师：陈小元 教授
2020-2021 浙江大学 高分子系 研究助理 导师：毛峥伟 教授 & 陈小元 教授
2019-2020 中科院长春应化所 无机化学 研究助理 导师：任劲松 研究员 & 曲晓刚 研究员
【研究领域】
细胞与微生物治疗的转化应用
纳米催化医学
纳米探针用于成像与传感
【代表性科研项目】
1. 2023 新加坡卫生部青年基金（OFYIRG23jul-0013,约人民币180万）, 国家医学研究委员会，主持
2. 2024 国家自然科学基金优秀青年科学基金项目（海外），国家自然科学基金委员会，主持
3. 2025 北京市自然科学基金联合基金（KZ66-0247-01），主持
4. 2025 中央高校基本科研业务费项目（KG16-4184-01），主持
5. 2025 年度国家外国专家项目（个人类）（12191044），主持
【代表性论著】
第一作者或共同通讯作者论文：
[1] Fangfang Cao, Lulu Jin, Yong Gao, Yuan Ding, Hongyang Wen, Zhefeng Qian, Chenyin Zhang, Liangjie Hong, Huang Yang, Jiaojiao Zhang, Zongrui Tong, Weilin Wang*, Xiaoyuan Chen*, Zhengwei Mao*. Artificial-enzymes-armed Bifidobacterium longum probiotics for alleviating intestinal inflammation and microbiota dysbiosis. Nat. Nanotechnol. 2023, 18, 617. (Hot paper)
[2] Fangfang Cao†, Lulu Jin†, Chenyin Zhang, Yong Gao, Zhefeng Qian, Hongyang Wen, Sisi Yang, Ziqiang Ye, Liangjie Hong, Huang Yang, Zongrui Tong, Liang Cheng, Yuan Ding, Weilin Wang, Guocan Yu*, Zhengwei Mao*, Xiaoyuan Chen*. Engineering clinically relevant probiotics with switchable “nano-promoter” and “nano-effector” for precise tumor therapy. Adv. Mater. 2023, 36, 2304257.
[3] Fangfang Cao, Lu Zhang, Yawen You, Lirong Zheng, Jinsong Ren*, Xiaogang Qu*. An enzyme-mimicking single-atom catalyst as an efficient multiple reactive oxygen and nitrogen species scavenger for sepsis management. Angew. Chem. Int. Ed. 2020, 59, 5108. (Highly cited paper)
[4] Meiqi Cheng, Xinyang Yu, Shaolong Qi, Kai Yang, Meixin Lu, Fangfang Cao*, Guocan Yu*. Development of organ targeting lipid nanoparticles with low immunogenicity and its application in the treatment of pulmonary fibrosis. Angew. Chem. Int. Ed. 2024, 63, e202407398.
[5] Chunxiong Zheng†, Qingguo Zhong†, Ke Yi, Huimin Kong, Fangfang Cao*, Chenya Zhuo, Yanteng Xu, Run Shi, Enguo Ju, Wantong Song, Yu Tao*, Xiaoyuan Chen*, Mingqiang Li*. Anti-phagocytosis-blocking repolarization-resistant membrane-fusogenic liposome (ARMFUL) for adoptive cell immunotherapy. Sci. Adv. 2023, 9, eadh2413.
[6] Yongfang Zheng†,*, Xinyu Zhang†, Mingyi Jiang, Fangfang Cao†,*, Qing You†,*, Xiaoyuan Chen*. Development and applications of D-amino acid derivatives-based metabolic labeling of bacterial peptidoglycan. Angew. Chem. Int. Ed. 2024, 63, e202319400.
[7] Yining Chen†, Tianshu Zou†, Gaoying Xin, Xin Liu, Yunan Yang, Liqi Wei, Biao Zhang, Pengcheng Yu, Yiping Ren, Yanlin Feng, Rui Chen*, Fangfang Cao*, Xiaoyuan Chen*, Yan Cheng*. Oxygen-independent synchronized ROS generation and hypoxia prodrug activation with Z-scheme heterostructure sonosensitizer. Adv. Mater. 2024, 36, 2307929.
[8] Fangfang Cao, Lu Zhang, Huan Wang, Yawen You, Ying Wang*, Nan Gao, Jinsong Ren*, Xiaogang Qu*. Defect-rich adhesive nanozymes as efficient “antibiotics” for enhanced bacterial inhibition. Angew. Chem. Int. Ed. 2019, 58, 16236. (Highly cited paper)
[9] Molin Liu†, Jian Zheng†, Mengqi Yu†, Qirui Wang, Yi Yuan, Nannan Shao, Xiaoliang Yang, Tianxi Shen, Li Wang, Aiyun Li, Rui Liu, Jimin Cao*, Xi Liu*, Fangfang Cao*, Yanlin Feng*. Stimuli-responsive CuFeTe2 nanosheets for amplified cuproptosis/ferroptosis in triple-negative breast cancer therapy. Adv. Sci. 2025. https://doi.org/10.1002/advs.202505739. (Invited)
[10] Yangfan Wang, Xiangyu Yang, Miya Zhang, Jiaqi Lei, Shaolong Qi, Kai Yang, Yongcan Li, Wenjie Zhang, Meiqi Cheng, Sheng Wang*, Jinqun Gan, Fangfang Cao*, Ruibing Wang*, Guocan Yu*. Supramolecular microspheres fabricated from macrocycle-incorporated polymers and their biomedical applications based on host-guest recognition. Small Methods 2025, 9, e01053.
[11] Chenyin Zhang, Fangfang Cao*, Yong Gao, Lulu Jin, Zongrui Tong, Zhengwei Mao*, Jiajun Zhu*. Microneedle patches loaded with bacterial attractants and nanozymes for targeting treatment of infection. Nano. Res. 2025, 18, 94907821.
[12] Yaling Liu, Shuwen Sun, Chunyao Shang, Rongji Liu, Chenhao Zhang, Jing Yu, Kai Dong*, Chen Xu*, Fangfang Cao*. MOF-derived nanozymes loaded with botanicals as multifunctional nanoantibiotics for synergistic treatment of intracellular antibiotic-resistant bacterial infection. Nanoscale Horiz. 2025, 10, 1377. (Invited)
[13] Kai Dong, Wenbo Lin, Tianyu Zhu, Shuwen Sun, Chenhao Zhang, Chen Xu*, Fangfang Cao*, Xiaoyuan Chen*. NIR-actuated botanicals/nanozymes nanofibrous membranes for antibiotic-free triple-synergistic therapy against polymicrobial wound infections. Adv. Healthcare Mater. 2024, 2401657. (Invited)
[14] Yanlin Feng†, Jianlin Wang†, Jimin Cao*, Fangfang Cao*, Xiaoyuan Chen*, Manipulating calcium homeostasis with nanoplatforms for enhanced cancer therapy. Exploration 2024, 4, 20230019. (Invited)
[15] Fangfang Cao. In vitro nanomaterial testing: unveiling biases through biomolecular corona influence. Nanoscale Horiz. 2024, 9, 1070. (Editorial, Invited)
[16] Yanlin Feng†, Xin Ning†, Jianlin Wang, Zhaoyang Wen, Fangfang Cao*, Qing You, Jianhua Zou, Xin Zhou, Teng Sun, Jimin Cao*, Xiaoyuan Chen*. Mace-like plasmonic Au-Pd heterostructures boost near-infrared photoimmunotherapy. Adv. Sci. 2023,10, 2204842.
[17] Yanlin Feng†, Jianlin Wang†, Xin Ning, Aiyun Li, Qing You, Wanzhen Su, Deping Wang, Jianyun Shi, Lan Zhou, Fangfang Cao*, Xiaoyuan Chen*, Jimin Cao*. BaTiO3@Au nanoheterostructure suppresses triple-negative breast cancer by persistently disrupting mitochondrial energy metabolism. Nano. Res. 2023, 16, 2775.
[18] Xinyang Yu†, Shaolong Qi†, Fangfang Cao†, Kai Yang, Hongjian Li, Kun Peng, Zhida Liu*, Bing Bai, Marija Buljan*, Xiaoyuan Chen*, Guocan Yu*. Fabrication of an immunostimulatory supramolecular nanomedicine for potent cancer chemoimmunotherapy. JACS Au 2023, 3, 3181.
[19] Fangfang Cao, Yanjuan Sang, Chaoying Liu*, Fuquan Bai, Lirong Zheng, Jinsong Ren*, Xiaogang Qu*. Self-adaptive single-atom catalyst boosting selective ferroptosis in tumor cells. ACS Nano 2022, 16, 855. (Highly cited paper)
[20] Fangfang Cao, Yan Zhang, Yuhuan Sun, Zhenzhen Wang, Lu Zhang, Yanyan Huang, Chaoqun Liu, Zhen Liu, Jinsong Ren*, Xiaogang Qu*. Ultrasmall nanozymes isolated within porous carbonaceous frameworks for synergistic cancer therapy: enhanced oxidative damage and reduced energy supply. Chem. Mater. 2018, 30, 7831.
[21] Fangfang Cao, Enguo Ju, Yan Zhang, Zhenzhen Wang, Chaoqun Liu, Wei Li, Yanyan Huang, Kai Dong, Jinsong Ren*, and Xiaogang Qu*. An efficient and benign antimicrobial depot based on silver-infused MoS2. ACS Nano 2017, 11, 4651.
[22] Fangfang Cao, Enguo Ju, Chaoqun Liu, Wei Li, Yan Zhang, Kai Dong, Zhen Liu, Jinsong Ren*, Xiaogang Qu*. Encapsulation of aggregated gold nanoclusters in a metal-organic framework for real-time monitoring of drug release. Nanoscale 2017, 9, 4128.
[23] Fangfang Cao, Enguo Ju, Chaoqun Liu, Fang Pu*, Jinsong Ren*, Xiaogang Qu*. Coupling a DNA-ligand ensemble with Ag cluster formation for the label-free and ratiometric detection of intracellular biothiols. Chem. Commun. 2016, 52, 5167.
专利转化：
1. 曹芳芳，毛峥伟，陈小元。一种提高肠道益生菌在口服递送过程中存活率的方法。中国专利，授权公告号：CN 113893353 B。
2. 陈小元，毛峥伟，曹芳芳。Artificial enzyme-bacteria system and uses thereof。国际专利，授权公告号：PCT/SG2022/050638。已经向新加坡卫生科学局提交保健品审批，和日本Zeria Pharmaceuticals签署NDA并开展临床前评估，并与中国杏湖产业园签署项目合作协议。
3. 陈小元，毛峥伟，曹芳芳。一种可靶向肠道肿瘤的抗癌复合物及其制备方法和应用。中国专利，授权公告号：CN 113925974 B。
4. 陈小元，曹芳芳。Metal Oxides Nanoparticles and Uses Thereof。国际专利，授权公告号：PCT/SG2025/050346。
【学术兼职】
2023 - 至今 受邀担任RSC 旗下 Nanoscale Horizons期刊青年编委
【所获奖励】
1. 2025 入选2024年度麻省理工科技评论“35岁以下科技创新35人”（TR35） 中国榜单（全国仅35人）
2. 2024 国家自然科学基金优秀青年科学基金项目获得者（海外）
3. 2017 博士研究生国家奖学金
【参加学术会议】
1. 2025年04月 2025年中国生物物理学会纳米酶分会年会暨第四届中国纳米酶大会暨北洋智医论坛（邀请）
2. 2024年12月 重庆医科大学（邀请）
3. 2024年06月 纳米生物学与纳米生物材料2024年崖州会议（邀请）
4. 2024年06月 中国化学会第34届学术年会（口头）
5. 2024年06月 广州医科大学生物医学工程学院之“康复工程创新论坛”系列讲座（十九）（邀请）
6. 2024年05月 第四届中国微米纳米技术学会微纳米技术与医疗健康创新大会（口头）
7. 2023年08月 ChinaNANO 2023，第九届纳米科学与技术国际会议（邀请）
8. 2023年02月 清华大学（邀请）
