张永彪 医工百人、副研究员、博士生导师
医工交叉创新研究院 大数据精准医疗高精尖创新中心
北航教师个人主页：http://shi.buaa.edu.cn/zhangyb/zh_CN/index.htm
电子邮箱： zhangyongbiao@buaa.edu.cn
【教育背景】
2003.8-2008.7 中国医学科学院-中国协和医科大学/清华大学 | 遗传学 | 博士学位（导师，褚嘉佑）
1999.9-2003.7 云南大学 | 遗传学 | 学士学位
【工作经历】
2018.4 - 至今 北京航空航天大学 | 大数据精准医疗高精尖创新中心 | 副研究员
2013.1 – 2018.4 中科院北京基因组研究所 | 基因组科学与信息重点实验室 | 副研究员
2008.8 - 2012.12 中科院北京基因组研究所 | 基因组科学与信息重点实验室 | 助理研究员
【研究领域】
[1] 疾病病因学
[2] 生物信息学
[3] 多组学
[4] 人工智能
【代表性科研项目】
1. 国家自然科学基金面上项目，8217062132、FOXI3异常相分离诱发半侧颜面短小畸形的机制和干预研究，2022/01-2025/12、54万元、在研、主持。
2. 国家自然科学基金面上项目，81970898、单细胞转录组揭示左右侧神经嵴细胞异常发育导致神经嵴病的机制，2020/01-2023/12、55万元、在研、主持。
3. 北自然-教委联合重点项目，中国儿童肥胖的风险基因和干预靶标研究，2019/01-2021/12，80万元、在研，参加。
4. 国家自然科学基金面上项目，31671312、ROBO1基因调控区突变鉴定及其导致人类半侧颜面短小畸形的功能研究，2017/01-2020/12、60万元、结题、主持。
5. 国家自然科学基金面上项目，31371347、应用全外显子组测序技术鉴定我国外中耳畸形的致病基因及功能研究、2014/01-2017/12、80万元、结题、主持。
6. 北京市教委科技计划重点项目，KZ201410025023、新型包涵体肌病家系致病基因的定位和病理功能研究研究、2014/01-2016/12、50万、结题、参与。
7. 国家自然科学基金青年项目，31201006、全外显子组测序鉴定非综合征型先天小耳畸形家系致病突变、2013/01-2015/12、23万元、结题、主持。
8. 国家自然科学基金面上项目，81170033、基于肥大细胞级联激活信号转导网络的哮喘易感基因研究、2013/01-2013/12、11万元、结题、参与。
9. 中国科学院知识创新项目，应用全外显子组测序技术鉴定唇腭裂致病基因、2012/01-2013/12、15万、结题、主持。
10. 国家自然科学基金青年项目，81101440、PDGF信号通路相关基因突变与非综合征型唇腭裂的关联研究、2012/01-2014/12、23万元、结题、参与。
11. 国家自然科学基金面上项目，30972816、应用SNP和单体型分析筛查我国新诊2型糖尿病患者早期大血管病变易感基因的研究、2011/01-2013/12、30万元、结题、参与。
【代表性论著】
1. Xiaopeng Xu#, Bingqing Wang#, Zhuoyuan Jiang, Qi Chen, Ke Mao, Xiaofeng Shi, Chun Yan, Jintian Hu, Yan Zha, Chao Ma,
Jiao Zhang, Rui Guo, Liguo Wang, Shouqin Zhao, Huisheng Liu, Qingguo Zhang*,Yong-Biao Zhang*,Novel risk factors for craniofacial microsomia and assessment of their utility in clinic diagnosis, Human Molecular
Genetics, 2021, 30(1)
2. Fujun Jin#, Junhui Li#, Yong-Biao Zhang#, Xiangning Liu#, Mingxiang Cai, Meijing Liu, Mengyao Li, Cui Ma, Rui Yue, Yexuan Zhu, Renfa Lai, Zuolin Wang,
Xunming Ji, Huawei Wei, Jun Dong, Zhiduo Liu, Yifei Wang*, Yao Sun*, Xiaogang Wang*, A functional motif of long noncoding
RNA Nron against osteoporosis, Nature Communications, 2021, 12:3319 , https://doi.org/10.1038/s41467-021-23642-7.
3. Yu Xu#, Yong-Biao Zhang#, Lijun Liang, Jiali Tian, Jinming Lin, Panpan Wang, Ronghui Li, Mingliang Gu*, Zhancheng Gao*, NAPG mutation
in family members with hereditary hemorrhagic telangiectasia in China, BMC Pulmonary Medicine, 2021,21:197,doi:10.1186/s12890-021-01524-4.
4. Ke Mao#, Meixian Zhang#, Jinshuai Cao, Xiaoyuan Zhao, Liwang Ga, Liwan Fu, Hong Cheng, Chun Yan,
Xiaopeng Xu, Xiaofeng Shi, Zhuoyuan Jiang, Bingqing Wang, Yong-Biao Zhang*, Jie Mi*, Coding Variants Are Relevant to the Expression of Obesity‐related Genes for Pediatric Adiposity, Obesity, 2020, 21 December 2020, https://doi.org/10.1002/oby.23046.
5. Yan Lu, Yu-Wei Da*, Yong-Biao Zhang*, Xin-Gang Li, Min Wang, Li Di, Mi Pang,Lin Lei, Identification of the CFTR c.1666A>G Mutation in Hereditary Inclusion Body Myopathy
Using Next-Generation Sequencing Analysis, Front. Neurosci., 22 May 2018，doi: 10.3389/fnins.2018.00329
6. Hui Qi#, Yong-Biao Zhang#, Lin Sun#, Cheng Chen#, Biao Xu, Fang Xu, Jia-Wen Liu, Jin-Cheng Liu, Chen Chen, Wei-Wei Jiao, Chen Shen, Jing Xiao, Jie-Qiong Li, Ya-Jie Guo, Yong-Hong Wang, Qin-Jing Li, Qing-QinYin, Ying-Jia Li, Ting Wang, Xing-Yun Wang, Ming-Liang Gu, Jun Yu, A-Dong Shen*, Discovery of Susceptibility Loci Associated with Tuberculosis in Han Chinese, Human Molecular Genetics,
2017, 26, 23:4752–4763
7. Yong-Biao Zhang#*, J Hu#, J Zhang, X Zhou, X Li, C Gu, T Liu, Y Xie, Dr. J Liu , M Gu , P Wang, T Wu, J Qian , Y Wang , J Yu ,
Q Zhang*. Genome-wide Association Study Identifies Multiple Susceptibility Loci For Craniofacial Microsomia,
Nature Communications, 7: 10605, 2016
8. Z Gu#, B Wang#, Yong-Biao Zhang#*, H Ding, Y Zhang, J Yu, M Gu, P Chan, N Cai*, Association of ARNTL and PER1 genes with Parkinson’s disease: a case-control study of Han Chinese. Scientific Reports, 5, 15891; doi: 10.1038/srep15891, 2015
9. F Chen#*, Q Li#, M Gu, X Li, J Yu, Yong-Biao Zhang*, Identification of a Mutation in FGF23 Involved in Mandibular Prognathism, Scientific Reports, 2015 Jun 10;5:11250.
doi: 10.1038/srep11250
10. L-Y Sun#, Yong-Biao Zhang#, L Jiang, N Wan, W-F Wu, X-D Pan, J Yu, F Zhang*, L Wang*, Identification of the gene defect responsible for severe hypercholesterolaemia using whole-exome sequencing, Scientific Reports, 2015 Jun 16;5:11380. doi: 10.1038/srep11380
11. X Li#, J Hu#, J Zhang, Q Jin, D-M Wang, J Yu, Q Zhang*, Yong-Biao Zhang*, Genome-Wide Linkage Study Suggests a Susceptibility Locus for Isolated Bilateral Microtia on 4p15.32–4p16.2, PLoS One, 2014, 9(7)
12. Yong-Biao Zhang#, X Li#, F Zhang*,D-M Wang, J Yu. A preliminary study of copy number variation in Tibetans. PLoS One, 7(7):e41768, 2012
13. B Wang#, Yong-Biao Zhang#, F Zhang, H Lin, X Wang, N Wan, Z Ye, H Weng, L Zhang, X Li, J Yan, P Wang, T Wu, L Cheng, J Wang, D-M Wang*, X Ma*, Jun Yu. On the Origin of Tibetans and their Genetic Basis in Adapting High-Altitude Environments. PLoS One, 6(2): e17002, 2011
14. Yong-Biao Zhang#, F Zhang, H Lin, L Shi, P Wang, Q Gong, X Li, M Wang, S Hu, J Chu*, D-M Wang*. Nucleotide polymorphism of the TNF gene cluster in six Chinese populations. J Hum Genet 55: 350-357, 2010
15. Shang C, Zhang YB, Qin HY, He BQ, Zhang CH, Sun JX, et al. Review on wavelength-tunable pulsed fiber lasers based on 2D materials. Opt Laser Technol 2020;131.
16. Yang, M., Yan, C., Griffith, M., Zhao, J., Zhang, Yong-Biao, Xie, D., Yan, J. Arabidopsis EED1 encoding a plant-specific nuclear protein is essential for early embryogenesis, J Genet Genomics, 2020,47,1:61-64
17. Di Wu, et al, Yong-Biao Zhang, Yuchuan Ding, Xunming Ji, Selective Intra-Arterial Brain Cooling Improves Long-Term Outcomes in a Non-Human Primate Model of Embolic Stroke: Efficacy Depending on Reperfusion Status, J Cereb Blood Flow Metab, 3 Mar 2020
18. Wu D, Fu Y, Wu L, Huber M, Chen J, Yao T, Zhang M, Wu C, Song M, He X, Li S, Zhang Yong-Biao, Li S, Ding Y and Ji X. Reperfusion plus Selective Intra-arterial Cooling (SI-AC) Improve Recovery in a Nonhuman Primate Model of Stroke. Neurotherapeutics. 2020.
19. Guo R, Wang B, Wang Y, Zhang Y, Liu T and Zhang Q. Epidemiological Analysis and the Nomogram for Possible Risk Factors
for Severe Microtia. J Craniofac Surg. 2020.
20. Wang Y, Ma C, Jiang C, Zhang Y and Wu D. A Novel IRF6 Variant Detected in a Chinese Family With Nonsyndromic Cleft Lip
and Palate by Whole Exome Sequencing. J Craniofac Surg. 2020.
21. Yao Sun, Mingxiang Cai, et al, Yong-Biao Zhang, Dong Jiang, An Hong, Xunming Ji, Zuolin Wang, Gong Zhang & Xiaogang Wang. The long noncoding RNA lnc-ob1 facilitates bone formation by upregulating Osterix in osteoblasts. Nature Metabolism 1, 485–496 (2019)
22. Wang Mei, Wu Di, Yong-Biao Zhang, et al. Interaction between IRF6 and GLRB shows protective effect on developing non-syndromic cleft lip with or without palate in the Han Chinese population, European Journal of Oral Sciences, 2019 Feb;127(1):27-32
23. Hu JT#, Chen Q#, Song HY, Cao YL, Zhang Yong-Biao, Zhou X, Liu T, Zhang QG*. Seasonal Variations in Microtia of Chinese Population. J Craniofac Surg. 2018 Aug 7.
doi: 10.1097/SCS.0000000000004790.
24. Wenshan Xing, Yue Wang, Jin Qian, Bingqing Wang, Xu Zhou, Tun Liu, YongBiao Zhang, Qingguo Zhang, Aesthetic Auricular
Reconstruction in Adult Patients with Rib Cartilage Calcification Using a Modified Two-Step Technique, Aesthetic Plastic Surgery.
2018 August 7, doi: 10.1007/s00266-018-1206-y
25. Qing Lin Peng#, JinMing Lin#, YongBiao Zhang, XueZhi Zhang, PanPan Wang, TingTing Wu, Jun Yu,
XiaoQun Dong, MingLiang Gu*, GuoChun Wang*, Targeted capture sequencing identifies novel genetic variations in Chinese
patients with idiopathic inflammatory myopathies. International Journal of Rheumatic Diseases, 2018, 27(8):1619-1626.
26. Wenxi Jiang, Ronghui Li, Yongbiao Zhang, Panpan Wang, Tingting Wu, Jinming Lin, Jun Yu & Mingliang Gu. Mitochondrial
DNA Mutations Associated with Type 2 Diabetes Mellitus in Chinese Uyghur Population. Scientific Reports, volume 7,
Article number: 16989 (2017)
27. Jinming Lin, Yongbiao Zhang, Qinglin Peng, Hanbo Yang, Jingli Shi, Mingliang Gu, Wenming Zhao, Guochun Wang. Genetic
Association of HLA-DRB1 Multiple Polymorphisms with Dermatomyositis in Chinese Population. HLA, 2017 Dec;90(6):354-359
28. Cheng L, Hu JT, Zhou X, Li ZB, Zhang Yong-Biao, Cao YL, Zhang QG*, Liu T*. The Retrograde Transposition of the Remnant Earlobe in Patients With Low-Set Microtia. J Craniofac Surg. 2015, 26(7):2177-9,wos:000367905900032
29. Hu Jintian#, LiuTun, Zhou Xu, Zhang Yong-Biao, Zhang Qingguo*, Unlilateral microtia, dextrocardia and situs inversus totalis: A possible new association., Journal of Plastic
Reconstructive and Aesthetic Surgery, 2015, 68(2): 35-36,wos: 000348502400003
30. Hu Jin-Tian#, Liu Tun, Qian Jin, Zhang Yong-Biao, Zhou Xu, Zhang Qing-Guo, Occurrence of different external ear deformities in monozygotic twins: report of 2 cases., Plast Reconstr Surg Glob Open,
2014, 2(9): e206-e206
31. Hu J#, Zhang Q, Zhang Yong-Biao, Zhou X, Qian J, Liu T*, Partial helix defect repair by use of flap combined with ipsilateral conchal cartilage graft.,
Journal of Plastic Reconstructive and Aesthetic Surgery, 2014, 67(8): 1045-1049,wos: 000339796600013
32. Hu Jintian#, Liu Tun, Zhou Xu, Zhang Yong-Biao, Zhang Qingguo, Treatment of postburn ear defect with expanded upper arm flap and consequent expansion without skin grafting,
Annals of Plastic Surgery, 2014, 72(4): 398-401,wos: 000333178200007
33. Liu M#, Pan H, Zhang F, Zhang Yongbiao, Zhang YX, Zhu J, Fu W*, Zhang X*, Identification of TNM stage-specific genes in lung adenocarcinoma by genome-wide expression profiling, ONCOLOGY LETTERS, 2013, 6(3): 763-768,wos: 000322382700026
34. F Wang#, C Shu#, L Jia, X Zuo, Yong-Biao Zhang, A Zhou, W Qin, H Song, C Wei, F Zhang, Z Hong, M Tang, Duen-Mei Wang*, Jianping Jia*. Exploration of 16 candidate genes identifies the association of IDE with Alzheimer's disease in Han Chinese.
Neurobiol Aging 33(5):0, 2012,wos: 000302486200045
35. D Wu#, M Wang#, X Wang, N Yin, T Song, H Li, F Zhang, Yong-Biao Zhang, Z Ye, J Yu, D-M Wang*, Z Zhao*. Maternal Transmission Effect of a PDGF-C SNP on Cleft Lip with Palate from a Chinese. PLoS ONE 7(9):e46477, 2012,wos: 000309973900166
36. Lin Hua#, Li An#, Lin Li, Yong-Biao Zhang, Chen Wang*. A bioinformatics strategy for detecting the complexity of Chronic Obstructive Pulmonary Disease
in Northern Chinese Han Population. Genes Genet Syst 87(3):197-209, 2012,wos: 000309801100007
37. Xu wang#, Xin Li#, Feng Zhang, Yong-Biao Zhang, Liyuan Sun, Duen-Mei Wang, Lu-Ya Wang*. A Genome-Wide Linkage Scan of a Pedigree with Familial Hypercholesterolemia Identified Two Novel Susceptibility Loci on Chromosomes 3q25-26 and 21q22. PLoS ONE 6, e24838, 2011
38. L An#, T Yang, Yong-Biao Zhang, Y Lin, H Zhang, X Jiao, L Hua, H Dai, C Wang*. Association of SERPINE2 gene with the risk of chronic obstructive
pulmonary disease and spirometric phenotypes in northern Han Chinese population. Mol Biol Pep. 39, 1427-33, 2011
39. 朱沂#, 张晓莉*, 张忠辉, 张峰, 张永彪, 府伟灵. 利用全基因组SNP芯片筛查2型糖尿病患者大血管病变易感基因.第三军医大学学报.33,331-4, 2011
40. T Wang#, Y Huang#, X Xiao, D-M Wang, C Diao, F Zhang, L Xu, Yong-Biao Zhang, Wi Li, L Zhang, Y Zhang, X Sun, Q Zhang*. The association between common genetic variation in the FTO gene and
metabolic syndrome in Han Chinese. Chin Med J 123: 1852-1858, 2010
41. 顾明亮，汪业军，史磊，张永彪，褚嘉祐, 中国 3 个不同地域藏族群体线粒体 ATP6、ATP8 和 Cyt b 基因的比较：探查自然选择在基因组的印记，遗传，32(2):147-152, 2009
42. 顾明亮,汪业军,陈姝,张永彪. 线粒体基因与核基因协同表达的机制. 生命的化学. 29(6):803-811, 2009
43. 李援亚,张云孙,杜娟,高志勇,张永彪,王璐. 应用寡核苷酸芯片分析水稻花序相关基因在花序发育中的表达谱. 遗传, 25(6): 695-699. 2003
44. 张永彪,褚嘉佑. 表现遗传学与人类基因组,科学（上海），10.3969/j.issn.0368-6396.2007.03.010
45. 张永彪,褚嘉佑. 表观遗传学与人类疾病的研究进展. 遗传, 27(3):466-472, 2005
