李呈 讲师
北京航空航天大学/医学科学与工程学院
电子邮箱：li_cheng@buaa.edu.cn
【教育背景】
(1)2013-09至2019-09 华中科技大学 ，生物医学工程 ，博士学位（导师：赵元弟）
(2)2009-09至2013-06 唐山师范学院，生物技术，学士学位
【工作经历】
2019-09至今，北京航空航天大学，医学科学与工程学院，讲师
【研究领域】
(1)纳米材料用于肿瘤诊疗的创新技术
(2)纳米生物材料与肿瘤微环境调控
(3)生物材料与免疫治疗
【代表性科研项目】
(1)国家自然科学基金，青年项目，基于超声触发一氧化氮构建的仿生纳米载体用于增强肿瘤的声动力-免疫联合治疗的研究，2021.01至2023.12，24万，在研，结题。
(2)北京航空航天大学青年拔尖计划，基于多通路调节肿瘤微环境的仿生纳米载体用于肿瘤声动力免疫联合治疗，在研，2021.01-2024.12，50万元，主持。
(3)北京市自然科学基金，青年项目，炎症微环境响应的秋水仙碱纳米系统调控巨噬细胞焦亡改善动脉粥样硬化进程的研究，2024.01-2024.12.20万元，在研，参与。
(4)北京市自然科学基金，面上项目，miR-23a复合磁性纳米颗粒调控三阴性乳腺癌骨转移的机制研究，2021.01至2023.12，20万，在研，结题。
(5)国家自然科学基金委员会，面上项目，基于智能人工蛋白和介孔硫化银构建肿瘤纳米荧光/光声/CT高分辨成像探针及其同步光热和光门控精准给药治疗研究，2018-01至2021-12，55万，在研，结题。
(6)国家自然科学基金委员会，面上项目，基于“分子阀门”的硫化银量子点/介孔硅可控释放系统用于靶向基因和药物共转运的实时示踪研究，2015-01至2018-12，80万，结题，参加。
【代表性论著】
(1)Yuanyuan Zhang; Yujie Zhang; Yonghong Li; Yuhan Fu; Yuanru Zhao; Wei Zhao; Runqing Li; Yao Xian; Kangsheng Tu; Feng Wu; Cheng Li*; Yuzhu Hou*; Mingzhen Zhang*; Harnessing Ag2S quantum dots with immune adjuvant for NIR-II fluorescence imaging-guided sonodynamic immunotherapy of colon cancer, Chemical Engineering Journal, 2023, 474: 145685.
(2)Jiale Cai; Guiping Hu; Lihua Hu; Junge Chen; Dan Chen; Dan Liu; Xiaolei Wang; Boxian Hu; Cheng Li*; A CaCO3-based nanoplatform with sonodynamic and tumor microenvironment activated for combined in vitro cancer therapy, Translational Oncology, 2023, 38: 101771.
(3)Li Cheng, Yang Xiao-Quan, An Jie, Cheng Kai, Hou Xiao-Lin, Zhang Xiao-Shuai, Hu Yong-Gou, Liu Bo, Zhao Yuan-Di. Red blood cell membrane-enveloped O2 self-supplementing biomimetic nanoparticles for tumor imaging-guided enhanced sonodynamic therapy, Theranostics, 2020, 10(2):867-879.
(4)Li Cheng, Yang Xiao-Quan, An Jie, Cheng Kai, Hou Xiao-Lin, Zhang Xiao-Shuai, Song Xian-Lin, Huang Kai-Chen, Chen Wei, Liu Bo, Zhao Yuan-Di, Liu Tian-Cai. A near-infrared light-controlled smart nanocarrier with reversible polypeptide-engineered valve for targeted fluorescence-photoacoustic bimodal imaging-guided chemo-photothermal therapy, Theranostics, 2019, 9(25):7666-7679.
(5)Li Cheng#, Yang Xiao-Quan#, Zhang Ming-Zhen, Song Yuan-Yang, Cheng Kai, An Jie, Zhang Xiao-Shuai, Xuan Yang, Liu Bo, Zhao Yuan-Di*. In vivo imaging-guided nanoplatform for tumor targeting delivery and combined chemo-, gene-and photothermal therapy, Theranostics, 2018, 8(20): 5662-5675.
(6)Song Yuan-Yang#, Li Cheng#, Yang Xiao-Quan#, An Jie, Cheng Kai, Xuan Yang, Shi Xue-Meng, Gao Meng-Juan, Song Xian-Lin, Zhao Yuan-Di*, Chen Wei*. Graphene oxide coating core–shell silver sulfide@mesoporous silica for active targeted dual-mode imaging and chemo-photothermal synergistic therapy against tumors, Journal of Materials Chemistry B, 2018, 6(29): 4808-4820.
(7)An Jie, Hu Yong-Gou, Li Cheng, Hou Xiao-Lin, Cheng Kai, Zhang Bin, Zhang Ruo-Yun, Li Dong-Yu, Liu Shao-Jun, Liu Bo, Zhu Dan, Zhao Yuan-Di. A pH/Ultrasound dual-response biomimetic nanoplatform for nitric oxide gas-sonodynamic combined therapy and repeated ultrasound for relieving hypoxia. Biomaterials, 2020, 230: 119636.
(8)An Jie, Hu Yong-Gou, Cheng Kai, Li Cheng, Hou Xiao-Lin, Wang Gang-Lin, Zhang Xiao-Shuai, Liu Bo, Zhao Yuan-Di, Zhang Ming-Zhen. ROS-augmented and tumor-microenvironment responsive biodegradable nanoplatform for enhancing chemo-sonodynamic therapy. Biomaterials, 2020, 234: 119761.
(9)Fang Bi-Yun, Li Cheng, Song Yuan-Yang, Tan Fang, Cao Yuan-Cheng, Zhao Yuan-Di. Nitrogen-doped graphene quantum dot for direct fluorescence detection of Al3+ in aqueous media and living cells. Biosensors Bioelectron, 2018, 100: 41-48.
(10)Fang Bi-Yun, Li Cheng, An Jie, Zhao Sun-Duo, Zhuang Zhi-Yong, Zhao Yuan-Di, Zhang Yue-Xuan. HIV-related DNA detection through switching on hybridized quenched fluorescent DNA-Ag nanoclusters. Nanoscale, 2018, 10(12): 5532-5538.
【招生】
欢迎具有材料、医学和生命科学等相关专业背景的优秀学子加入。有意者可直接发送简历至邮箱：li_cheng@buaa.edu.cn。
