张靖 教授
医工交叉创新研究院 生物医学工程高精尖创新中心
北航教师个人主页：http://shi.buaa.edu.cn/jz2716/zh_CN/index.htm
电子邮箱：jz2716@buaa.edu.cn
【教育背景】
[1] 2005.9-2009.6 中国科学院自动化研究所 | 控制科学与工程 | 博士学位 | 博士研究生毕业
[2] 2002.9-2005.6 哈尔滨理工大学 | 计算机科学与技术 | 硕士学位 | 硕士研究生毕业
[3] 1998.9-2002.6 哈尔滨理工大学 | 控制科学与工程 | 学士学位 | 大学本科毕业
【工作经历】
[1] 2019.6-至今 北京航空航天大学 | 教授
[2] 2015.7-2019.6 Columbia University | Associate Research Scientist
[3] 2014.1-2015.6 中国科学院北京基因组研究所 | 副研究员
[4] 2009.7-2013.12 中国科学院北京基因组研究所 | 助理研究员
【研究领域】
[1] 深度学习方法开发，以解决肿瘤发生发展，预后，免疫相关科学问题
集中在开发深度学习(Deep Learning)模型和方法，特别是概率模型和新颖的推断方法，通过新的深度学习方法学习实体肿瘤多组学数据的内在规律和表示层次，解决肿瘤发生发展，预后，免疫相关的科学问题。
[2] 机器学习方法应用，研究免疫系统与肿瘤发生发展之间的交互作用关系
机器学习（Machine Learning）是人工智能技术的核心，主要集中在开展各种机器学习方法的应用，通过挖掘多组学数据研究免疫系统如何与肿瘤细胞之间相互作用，开发出能杀死肿瘤细胞的疫苗。
[3] 机器学习方法开发，开发针对肿瘤和病毒的多肽疫苗
新的机器学习方法的开发，主要集中在开发新的机器学习方法，从高通量组学数据中进行特征提取与模式识别，鉴定具有高质量免疫原性的肿瘤疫苗、病毒疫苗等，并进行体外、动物实验，开发疫苗，防止重大疾病和传染病的产生。
[4] 转基因动物模型构建， 从分子生物学的机制层面研究肿瘤免疫、多肽疫苗相关的科学问题构建转基因动物模型，在活体动物上验证大规模计算发现。
[5] 生物医学诊疗平台的开发
开发生物医学诊疗平台，实现人工智能个性化治疗。
【代表性论著】
2021年
Zixuan Xiao, Wei Zhang, Guanzhang Li, Wendong Li, Lin Li, Ting Sun, Yufei He, Guang Liu, Lu Wang,
Xiaohan Han, Hao Wen, Yong Liu, Yifan Chen, Haoyu Wang, Jing Li, Yubo Fan#, Jing Zhang#. Multiomics
analysis reveals the prognostic non-tumor cell landscape in glioblastoma niches. Frontiers in Genetics, 2021, Sept 16; 12:741325 (#通讯作者)
Ting Sun, Yufei He, Wendong Li, Guang Liu, Lin Li, Lu Wang, Zixuan Xiao, Xiaohan Han, Hao Wen,
Yong Liu, Yifan Chen, Haoyu Wang, Jing Li, Yubo Fan#, Jing Zhang#. neoDL: a novel neoantigen intrinsic
feature-based deep learning model identifies IDH wild-type glioblastomas with the longest survival. BMC Bioinformatics, 2021, Jul 23; 22:382 (#通讯作者)
2020年
Lin Li, Ting Sun, Yufei He, Wendong Li, Yubo Fan#, Jing Zhang#. Epitope-based peptide vaccines predicted against novel coronavirus disease caused by SARS-CoV-2.Virus Research，2020，Oct 15; 288:198082 (#通讯作者)
Wendong Li, Lin Li, Ting Sun, Yufei He, Guang Liu, Zixuan Xiao, Yubo Fan#, Jing Zhang#. Spike protein-based epitopes predicted against SARS-CoV-2 through literature mining. Medicine in Novel Technology and Devices. 2020, Dec; 8:100048. (#通讯作者)
Francesca Pia Caruso,Luciano Garofano,Fulvio D'Angelo,Kai Yu,Fuchou Tang,Jinzhou Yuan,Jing Zhang,
Luigi Cerulo,Stefano M Pagnotta,Davide Bedognetti,Peter A Sims,Mario Suvà,Anna Lasorella,Xiao-Dong Su,Antonio Iavarone,Michele Ceccarelli. A map of tumor-host interactions in glioma at single-cell resolution. Gigascience, 2020, 9(10): giaa109
2019年
Jing Zhang, Francesca P. Caruso, Jason K. Sa, Sune Justesen, Do-Hyun Nam, Peter Sims, Michele Ceccarelli, Anna Lasorella, Antonio Iavarone. The combination of neoantigen
quality and T lymphocyte infiltrates identifies glioblastomas with the longest survival.
Communications Biology. 2019,2:135.
Xiaocui Xu*,Guoqiang Li*,Congru Li*,Jing Zhang*,Qiang Wang*,David K Simmons,Xuepeng Chen,Naveen
Wijesena,Wei Zhu,Zhanyang Wang,Zhenhua Wang,Bao Ju,Weimin Ci,Xuemei Lu,Daqi Yu,Qian-fei Wang,Neelakanteswar Aluru,Paola Oliveri,Yong E Zhang,Mark Q Martindale,Jiang Liu#. Evolutionary
transition between invertebrates and vertebrates via methylation reprogramming in embryogenesis.
National Science Review, 2019, nwz064.（*共同第一）
Jason K. Sa, Seung Won Choi, Junfei Zhao, Yeri Lee, Jing Zhang, Doo-Sik Kong, Jung Won Choi, Ho Jun Seol, Jung-II Lee, Antonio Iavarone, Raul Rabadan, Do-Hyun Nam. Hypermutagenesis in untreated adult gliomas due to inherited mismatch mutations. International
Journal of Cancer, 2019, 144 (12):3023-3030.
Yu Ren,Yun-fei Wang,Jing Zhang,Qi-xue Wang,Lei Han,Mei Mei,Chun-sheng Kang. Targeted design and identification of AC1NOD4Q to block activity of HOTAIR by abrogating
the scaffold interaction with EZH2. Clinical Epigenetics, 2019, 11(29).
Faping Shen,Chunyan Song,Yunmian Liu,Jing Zhang,SonyaWei Song. IGFBP2 Promotes Neural Stem Cell
Maintenance and Proliferation Differentially Associated with Glioblastoma Subtypes. Brain Research,
2019, 1704: 174-186.
2018年
Qixue Wang, Jinquan Cai, Chuan Fang, Chao Yang, Junhu Zhou, Yanli Yan, Yunfei Wang, Yansheng Li,
Xiangqi Meng, Kai Zhao, Kaikai Yi, Sijing Zhang, Jianning Zhang, Chuanlu Jiang#, Jing Zhang#,
Chunsheng Kang#. Mesenchymal glioblastoma constitutes a major ceRNA signature in the TGF-B pathway.
Theronostics,2018,8(17):4733-4749. (#通讯作者）
Veronique Frattini, Stefano Pagnotta, Tala, Jerry J. Fan, Marco V. Russo, Sang Bae Lee, Luciano
Garofano, Jing Zhang, Peiguo Shi, Genevieve Lewis, Heloise Sanson, Vanessa Frederick, Angelica M. Castano,
Luigi Cerulo, Delphine C. M. Rolland, Raghvendra Mall, Karima Mokhtari, Kojo S. J. Elenitoba-Johnson, Marc Sanson, Xi Huang, Michele Ceccarelli, Anna Lasorella, Antonio Iavarone. A metabolic
function of FGFR3-TACC3 gene fusions in cancer. Nature, 2018 Jan 11; 553(7687):222-227.
Fulvio D’Angelo, Michele Ceccarelli, Tala, Luciano Garofano, Jing Zhang, Veronique Frattini,
Francesca P Caruso, Genevieve Lewis, Kristin D. Alfaro, Luc Bauchet, Giulia Berzero, David Cachia,
Mario Cangiano, Laurent Capelle, John de Groot, Francesco DiMeco, Fracois Ducray, Walid Farah,
Gaetano Finocchiaro, Stephane Goutagny, Carlos Kamiya Matsuoka, Cinzia Lavarino, Hugues Loiseau,
Veronique Lorgis, Carlo E Marras, Ian McCutcheon, Do-Hyun Nam, Susanna Ronchi, Veronica Saletti, Romuald Seizeur, John Slopis, Mariona Sunol, Fanny Vandenbos,
Pascale Varlet, Dominiqu Vidaud, Colin Watts, David E Reuss, Seung-Ki Kim, Viviane Tabar, David Meyronet, Karima Mokhtari, Hector Salvador, Krishna P. Bhat, Marica Eoli,
Marc Sanson, Anna Lasorella, Antonio Iavarone. The molecular landscape of glioma in patients with
Neurofibromatosis 1. Nature Medicine, 2018, 25(1):176-187.
2016年
Wang Yunfang,Qin Jinhua,Wang Shuyong,Zhang Wencheng,Duan Jialei,Zhang Jing,Wang Xin,Yan Fang,Chang
Mingyang,Liu Xiaofang,Feng Bo,Liu Jiang,Pei Xuetao. Conversion of Human Gastric Epithelial Cells to
Multipotent Endodermal Progenitors using Defined Small Molecules. Cell stem cell, 2016, 19(4): 449-461.
2015年
Chen Ke*,Zhang Jing*,Guo Zhongqiang*,Ma Qin,Xu Zhengzheng,Zhou Yuanyuan,Xu Ziying,Li Zhongwu,Liu
Yiqiang,Ye Xiongjun,Li Xuesong,Yuan Bifeng,Ke Yuwen,He Chuan,Zhou Liqun,Liu Jiang,Ci Weimin. Loss of 5-hydroxymethylcytosine is linked to gene body hypermethylation in kidney cancer. Cell Research, 2015,
26: 103-118.(*共同第一）
Zou Dong,Sun Shixiang,Li Rujiao,Liu Jiang,Zhang Jing#,Zhang Zhang#. MethBank: a database integrating
next-generation sequencing single-base-resolution DNA methylation programming data. Nucleic Acids
Research, 2015, 43(Database issue): D54-D58.(#通讯作者）
Wang Lu,Zhang Jun,Duan Jialei,Gao Xinxing,Zhu Wei,Lu Xingyu,Yang Lu,Zhang Jing,Li Guoqiang,Ci Weimin,
Li Wei,Zhou Qi,Aluru Neel,Tang Fuchou,He Chuan,Huang Xingxu,Liu Jiang. Programming and inheritance
of parental DNA methylomes in mammals. Cell, 2015, 157(4).
Li Guoqiang,Ci Weimin,Karmakar Subhradip,Chen Ke,Dhar Ruby,Fan Zhixiang,Guo Zhongqiang,Zhang Jing,
Ke Yuwen,Wang Lu,Zhuang Min,Hu Shengdi,Li Xuesong,Zhou Liqun,Li Xianghong,Calabrese MatthewF,Watson
EdmondR,Prasad SandipM,Rinker-Schaeffer Carrie,Eggener ScottE,Stricker Thomas,Tian Yong,Schulman BrendaA,Liu Jiang,White KevinP..
SPOP promotes tumorigenesis by acting as a key regulatory hub in kidney cancer. Cancer Cell, 2015, 25(4): 455-468.
Han Haibo,Du Yantao,Zhao Wei,Li Sheng,Chen Dongji,Zhang Jing,Liu Jiang,Suo Zhenhe,Bian Xiuwu,Xing
Baocai,Zhang Zhiqian. PBX3 is targeted by multiple miRNAs and is essential for liver tumour-initiating cells. Nature Communications, 2015, 8271.
Zhou Xuan,Ren Yu,Zhang Jing,Zhang Chuanbao,Zhang Kailiang,Han Lei,Kong Lingping,Wei Jianwei,
Chen Luyue,Yang Jingxuan,Wang Qixue,Zhang Jianning,Yang Yuqi,Jiang Tao,Li Min,Kang Chunsheng.
HOTAIR is a therapeutic target in glioblastoma. Oncotarget, 2015, 6: 8353-8365
2013年
Jiang Lan*,Zhang Jing*,Wang Jing-Jing*,Wang Lu,Zhang Li,Li Guoqiang,Yang Xiaodan,Ma Xin,Sun Xin,Cai Jun,Zhang Jun,Huang Xingxu,Yu Miao,
Wang Xuegeng,Liu Feng,Wu Chung-I,He Chuan,Zhang Bo,Ci Weimin,Liu Jiang. Sperm, but Not Oocyte, DNA Methylome Is Inherited by Zebrafish
Early Embryos. Cell, 2013, 153(4): 773-784. (*共同第一）
Zhang Wei*,Zhang Jing*,Yan Wei,You Gan,Bao Zhaoshi,Li Shouwei,Kang Chunsheng,Jiang Chuanlu,You
Yongping,Zhang Yuxiang,Chen ClarkC,Song SonyaWei,Jiang Tao. Whole-genome microRNA expression
profiling identifies a 5-microRNA signature as a prognostic biomarker in Chinese patients with primary glioblastoma multiforme.
Cancer, 2013, 119(4): 814-824. (*共同第一）
Zhang Jun-Xia*,Zhang Jing*,Yan Wei*,Wang Ying-Yi,Han Lei,Yue Xiao,Liu Ning,You Yong-Ping,Jiang Tao,Pu Pei-Yu,Kang Chun-Sheng. Unique genome-wide map of TCF4 and STAT3 targets using ChIP-seq reveals their association with new molecular subtypes of glioblastoma. Neuro-Oncology, 2013, 15(3): 712-719. (*共同第一）
Lin Yi,Zhang Guozhen,Zhang Jing,Gao Guangzu,Li Min,Chen Yong,Wang Jiangfei,Li Guilin,Song Sonya-Wei,Qiu Xiaoguang,Wang Yunjie,Jiang Tao. A panel of four cytokines predicts the prognosis of patients
with malignant gliomas. Journal of Neuro-Oncology, 2013, 114(2): 199-208.
2012年
Zhang Wei*,Zhang Jing*,Hoadley Katherine,Kushwaha Deepa,Ramakrishnan Valya,Li Shouwei,Kang Chunsheng,
You Yongping,Jiang Chuanlu,Song SonyaWei,Jiang Tao,Chen Clark C.. MiR-181d: Predictive glioblastoma biomarker that downregulates MGMT expression. Neuro-Oncology, 2012,
14(6): 712-719.(*共同第一）
Li Yuchen*,Jiang Tao*,Zhang Jing*,Zhang Bin,Yang Wei,You Gan,Xu Kaiyu,Wu Jing,Luo Chenghua,Song SonyaW.
Elevated serum antibodies against insulin-like growth factor-binding protein-2 allow detecting early-stage cancers: evidences from glioma and colorectal carcinoma studies. Annals of Oncology, 2012, 23(9):
2415-2422.(*共同第一）
2011年
Tao Yong,Ruan Jue,Yeh Shiou-Hwei,Lu Xuemei,Wang Yu,Zhai Weiwei,Cai Jun,Ling Shaoping,Gong Qiang,Chong Zecheng,Qu Zhengzhong,Li
Qianqian,Liu Jiang,Yang Jin,Zheng Caihong,Zeng Changqing,Wang Hurng-Yi,Zhang Jing,Wang Sheng-Han,Hao Lingtong,Dong Lili,Li Wenjie,Sun Min,Zou Wei,Yu Caixia,Li Chaohua,Liu Guojing,Jiang Lan,Xu Jin,
Huang Huanwei,Li Chunyan,Mi Shuangli,Zhang Bing,Chen Baoxian,Zhao Wenming,Hu Songnian,Zhuang Shi-Mei,Shen Yang,Shi Suhua,Brown Christopher,White Kevin P.,Chen Ding-Shinn,Chen Pei-Jer,Wu Chung-I. Rapid growth of a hepatocellular carcinoma and the driving mutations revealed by cell-population genetic analysis of whole-genome data. Proc Natl Acad Sci U S A, 2011, 108(29): 12042-12047.
2010年
Fan Ming,Liu Bing,Jiang Tianzi,Jiang Xingpeng,Zhao Huizhi,Zhang Jing. Meta-analysis of the Association between the Monoamine Oxidase-A Gene and Mood Disorders. Psychiatric Genetics, 2010, 20(1): 1-7.
2009年
Zhang Jing,Liu Bing,Jiang Xingpeng,Zhao Huizhi,Fan Ming,Fan Zhenjie,Lee J.Jack,Jiang Tao,Jiang
Tianzi,Song SonyaWei. A Systems Biology-Based Gene Expression Classifier of Glioblastoma Predicts
Survival with Solid Tumors. PLoS ONE, 2009, 4(7): e6274.
Zhao Huizhi,Wang Dong,Liu Bing,Jiang Xingpeng,Zhang Jing,Fan Ming,Fan Zhenjie,Chen Ying,Song
SonyaWei,Gao Wei,Jiang Tianzi,Cui Qinghua. Recombination rates of human microRNA. Biochem
Biophys Res Commun, 2009, 379(3): 702-705.
2008年
Zhang Jing,Jiang Tianzi,Liu Bing,Jiang Xingpeng,Zhao Huizhi. Systematic benchmarking of microarray
data feature extraction and classification. International Journal of Computer Mathematics,
2008, 85(5): 803-811.
Jiang Xingpeng,Liu Bing,Jiang Jiefeng,Zhao Huizhi,Fan Ming,Zhang Jing,Fan Zhenjie,Jiang Tianzi.
Modularity in the genetic disease-phenotype network [Journal]. FEBS Lett, 2008, 582(17): 2549-2554.
2006年
Liu Bing,Jiang Tianzi,Ma Songde,Zhao Huizhi,Li Jun,Jiang Xingpeng,Zhang Jing. Exploring candidate
genes for human brain diseases from a brain-specific gene network. Biochem Biophys Res Commun,
2006, 349(4): 1308-1314.
2005年
Jing Xu, Zhang Jing. Hotspot clustering for ad hoc network. Proceedings of International Conference
on Wireless Communications, Networking and Mobile Computing, 2005, 2.
