刘婍 准聘副教授 硕士生导师 博士生导师
北京航空航天大学 医学科学与工程学院
电子邮箱：qiliu595@buaa.edu.cn
【教育背景】
[1] 2010.9-2016.6 中国科学院过程工程研究所生化工程国家重点实验室 生物化工 博士学位 博士研究生毕业 导师：马光辉院士
[2] 2006.9-2010.6 中国海洋大学 生物工程 学士学位 大学本科毕业
【工作经历】
2021.12至今 北京航空航天大学，医学科学与工程学院，准聘副教授
2017.8-2021.7 美国加州大学洛杉矶分校 加州纳米系统研究所、David Geffen医学院纳米医药系 博士后
合作导师：Distinguished Prof. Andre Nel, Prof. Tian Xia
【研究领域】
生物、医学、化学化工、材料、药剂学等多学科交叉
纳微药物制剂及其应用研究，包括纳微颗粒免疫耐受药物的开发及特异性耐受诱导与保持机制研究，纳微颗粒疫苗制剂的开发及免疫增强机制研究
【代表性科研项目】
1. 北京航空航天大学第十二批青年拔尖人才支持计划，纳微颗粒疫苗的研发和制备，在研，主持。
2. A. Nel, C. Charles, T. Xia, A. La Cava, M. Butte, Q. Liu, et al. Tolerogenic Nanoparticles for the Treatment of Allergy and Autoimmune Disorders ($125,000, 2019-2020, UCLA David Geffen School of Medicine)
3. Q. Liu, T. Xia, A. Nel. Liver Targeting Tolerogenic Nanoparticles for the Treatment of Peanut Allergy ($66,000, 2020-2021, UCLA David Geffen School of Medicine)
【代表性论著】
第一、通讯作者论文
1. Q. Liu, X Wang, T. Xia, A. Nel et al.; Use of a liver-targeting nanoparticle platform to intervene in peanut-induced anaphylaxis through delivery of an Ara h2 T-cell epitope, Nano Today, 2022, 42 (101370).
2. K Liu, Y Tao, L Wang, J Lei*, J Liu*, Q. Liu*. A novel multifunctional vaccine platform with dendritic cell-targeting and pH-responsive for cancer immunotherapy: antigen-directed biomimetic fabrication of a cabbage-like mannatide-zinc-antigen hybrid microparticles. Chemical Engineering Journal 15, (2021) 130867.
3. Q. Liu, X. Wang, T. Xia, A. Nel, et al. Antigen and Epitope Delivering Nanoparticles Targeting Liver Induce Comparable Immunotolerance in Allergic Airway Disease and Anaphylaxis as Nanoparticles Delivering Pharmaceuticals. ACS Nano 15 (2021) 1608.
4. Q. Liu, X. Wang, T. Xia, A. Nel, et al. Use of Polymeric Nanoparticle Platform Targeting the Liver to Induce Treg-Mediated Antigen-Specific Immune Tolerance in a Pulmonary Allergen Sensitization Model. ACS Nano 13 (2019) 4778.
5. Q. Liu, X. Wang, T. Xia, et al. Creative use of analytical techniques and high-throughput technology to facilitate safety assessment of engineered nanomaterials. Analytical and Bioanalytical Chemistry 24 (2018) 6097.
6. Q. Liu, X.M. Chen, G.H. Ma, et al. Potential hepatitis B vaccine formulation prepared by uniform-sized lipid hybrid PLA microparticles with adsorbed hepatitis B surface antigen. Molecular Pharmaceutics 15 (2018) 5227.
7. Q. Liu, J.L. Jia, G.H. Ma, et al. Pathogen mimicking polymeric nanoparticles based on dopamine polymerization as vaccines adjuvants induce robust humoral and cellular immune responses. Small 12 (2016) 1744.
8. Q. Liu, X.M. Chen, G.H. Ma, et al. pH-responsive PLGA nanoparticles with rapid antigen release behavior promote immune response. ACS Nano 9 (2015) 4925.
其他代表性论文
1. Jiulong Li, Linda M. Guiney, Xiang Wang, Chong Hyun Chang, Jinhong Jiang, Qi Liu, Xiangsheng Liu, Kuo-Ching Mei, Yu-Pei Liao, Tiancong Ma, Huan Meng, Mark C. Hersam, André E. Nel, Tian Xia, Dissolution of 2D molybdenum disulfide generates differential toxicity among liver cell types compared to non-toxic 2D boron nitride effects, Small, 2021, 17, 202101084. (DOI:10.1002/smll.202101084.)
2. Jiulong Li, Xiang Wang, Kuo-Ching Mei, Chong Hyun Chang, Jinhong Jiang, Xiangsheng Liu, Qi Liu, Linda M. Guiney, Mark C. Hersam, Huan Meng, Tian Xia. Lateral size of graphene oxide determines differential cellular uptake and cell death pathways in Kupffer cells, LSECs, and hepatocytes, Nano Today, 2021, 37, 101061
3. Xiangsheng Liu, Jinhong Jiang, Yu‐Pei Liao, Ivanna Tang, Emily Zheng, Waveley Qiu, Matthew Lin, Xiang Wang, Ying Ji, Kuo‐Ching Mei, Qi Liu, Chong Hyun Chang, Zev A Wainberg, Andre E Nel, Huan Meng. Combination Chemo-Immunotherapy for Pancreatic Cancer Using the Immunogenic Effects of an Irinotecan Silicasome Nanocarrier Plus Anti-PD-1. Advanced Science 8 (6), 2002147.
4. Kuo-Ching Mei, Yu-Pei Liao, Jinhong Jiang, Michelle Chiang, Mercedeh Khazaieli, Xiangsheng Liu, Xiang Wang, Qi Liu, Chong Hyun Chang, Xiao Zhang, Juan Li, Ying Ji, Brenda Melano, Donatello Telesca, Tian Xia, Huan Meng, Andre E Nel. Liposomal delivery of mitoxantrone and a cholesteryl indoximod prodrug provides effective chemo-immunotherapy in multiple solid tumors. ACS nano 14 (10), 13343-13366.
5. Xiang Wang, Chong Hyun Chang, Jinhong Jiang, Qi Liu, Yu‐Pei Liao, Jianqin Lu, Linjiang Li, Xiangsheng Liu, Joshua Kim, Ayman Ahmed, André E Nel, Tian Xia. The Crystallinity and Aspect Ratio of Cellulose Nanomaterials Determine Their Pro‐Inflammatory and Immune Adjuvant Effects In Vitro and In Vivo. Small 15 (42), 1901642.
6. Xiang Wang, Chong Hyun Chang, Jinhong Jiang, Xiangsheng Liu, Jiulong Li, Qi Liu, Yu‐Pei Liao, Linjiang Li, André E Nel, Tian Xia. Metal-Based Nanoparticles: Mechanistic Differences in Cell Death Responses to Metal‐Based Engineered Nanomaterials in Kupffer Cells and Hepatocytes. Small 16 (21), 2070113.
7. Ying Ji, Xiangsheng Liu, Max Huang, Jinhong Jiang, Yu-Pei Liao, Qi Liu, Chong Hyun Chang, Han Liao, Jianqin Lu, Xiang Wang, Melissa J Spencer, Huan Meng. Development of self-assembled multi-arm polyrotaxanes nanocarriers for systemic plasmid delivery in vivo. Biomaterials 192, 416-428.
8. Lianyan Wang, Qi Liu, Jilei Jia, Tingyuan Yang, Guanghui Ma. Design of pH-responsive poly(D, L-lactic-co-glycolic acid) nanoparticles to promote immune response. Journal of Controlled Release 259, e81.
9. Jilei Jia, Tingyuan Yang, Ting Lu, Qi Liu, Lianyan Wang, Guanghui Ma. Co-delivery of HBsAg and poly I: C by CaCO3 microspheres employing layer-by-layer technique. Journal of Controlled Release 259, e63.
10. Jilei Jia, Weifeng Zhang, Qi Liu, Tingyuan Yang, Lianyan Wang, Guanghui Ma. Adjuvanticity regulation by biodegradable polymeric nano/microparticle size. Molecular pharmaceutics 14 (1), 14-22.
11. Jilei Jia, Qi Liu, Tingyuan Yang, Lianyan Wang, Guanghui Ma. Facile fabrication of varisized calcium carbonate microspheres as vaccine adjuvants. Journal of Materials Chemistry B 5 (8), 1611-1623.
12. Weifeng Zhang, Lianyan Wang, Yuan Liu, Xiaoming Chen, Qi Liu, Jilei Jia, Guanghui Ma. Regulating the surface charges of polymeric microparticles to improve the efficacy of particle-adjuvanted vaccine. Journal of Controlled Release 2015 Sep 10;213:e113.
13. Weifeng Zhang, Lianyan Wang, Tingyuan Yang, Yuan Liu, Xiaoming Chen, Qi Liu, Jilei Jia, Guanghui Ma. Immunopotentiator-loaded polymeric microparticles as robust adjuvant to improve vaccine efficacy. Pharmaceutical Research 32 (9), 2837-2850.
14. Xiaoming Chen, Lianyan Wang, Qi Liu, Jilei Jia, Yuan Liu, Weifeng Zhang, Guanghui Ma, Zhiguo Su. Polycation-decorated PLA microspheres induce robust immune responses via commonly used parenteral administration routes. International Immunopharmacology 23 (2), 592-602.
15. Weifeng Zhang, Lianyan Wang, Yuan Liu, Xiaoming Chen, Qi Liu, Jilei Jia, Tingyuan Yang, Shaohui Qiu, Guanghui Ma. Immune responses to vaccines involving a combined antigen–nanoparticle mixture and nanoparticle-encapsulated antigen formulation. Biomaterials 35 (23), 6086-6097.
专利
1. A. Nel, T. Xia, Q. Liu, X. Wang. Single- and multi- epitope peptide and mRNA vaccines to generate tolerogenic effects for allergic and autoimmune disease by targeting liver sinusoidal endothelial cells. (US patent, 2021, submitted)
2. A. Nel, H. Meng, T. Xia, Q. Liu, et al. A nano-enabled vaccination approach for COVID-19 and other viral diseases. (US patent, 2020, submitted)
3. A. Nel, T. Xia, Q. Liu. Polymeric nanoparticles that target liver sinusoidal endothelial cells to induce antigen-specific immune tolerance. (US patent, 2019, submitted)
4. 王连艳，马光辉，刘婍等，一种胞内pH响应聚乳酸类纳微球及其制备方法（排名第三，已授权，CN106031794B）
5. 徐莹，汪东风，刘婍等，一种脱除水溶液中重金属镉的方法（排名第三，已授权，ZL200810185075.6）
