董再再 助理教授
医学科学与工程学院
电子邮箱：dongzaizai@buaa.edu.cn
【教育背景】
2014.09-2019.06 中国科学院化学研究所 分子纳米结构与纳米技术重点实验室 材料学 博士 指导老师：方晓红 研究员 （国家级人才、973项目首席科学家）
2010.09-2014.06 湘潭大学 化学学院 应用化学 理学学士
【工作经历】
2019.09-2022.06 北京航空航天大学 生物与医学工程学院 生物医学工程 博士后 合作导师：常凌乾 教授（国家级人才）
【研究领域】
细胞生物芯片，多功能DNA探针，肿瘤标志物检测，纳米电穿孔分子递送技术
【代表性科研项目】
主持课题4项：国家重点研发计划青年科学家项目 子课题 20万元；青海省科技厅医-康-养新模式基地建设重点专项 子课题 20万元；北航医工卓越创新计划 7万元；横向课题“药物递送纳米电穿孔芯片研发” 20万元。
参与国家自然科学基金；北京市自然科学基金；四川省科技厅重点研发项目；产业转化项目3项。
【代表性论著】
1. Zaizai Dong#, Shi Yan#, Bing Liu, Yongcun Hao, Long Lin, Tianrui Chang, Hong Sun, Yusen Wang, Hu Li, Han Wu, Xinxin Hang, Shiqi He, Jiaming Hu, Xinying Xue*, Nan Wu*, Lingqian Chang*. Single Living Cell Analysis Nanoplatform for High-Throughput Interrogation of Gene Mutation and Cellular Behavior. Nano Letters. 2021, 21(11): 4878-4886.
2. Zaizai Dong, Chuanhao Tang, Libo Zhao, Jiachao Xu, Yayun Wu, Xiaojun Tang, Wei Zhou, Rongxiang He, Rong Zhao, Li Xu, Zhen Zhang, Xiaohong Fang*. A Microwell-Assisted Multiaptamer Immunomagnetic Platform for Capture and Genetic Analysis of Circulating Tumor Cells. Advanced Healthcare Materials. 2018, 7(24): 1801231.
3. Zaizai Dong#, Yanli Jiao#, Bingteng Xie, Yongcun Hao, Pan Wang, Yuanyuan Liu, Junfeng Shi, Chandani Chitrakar, Stephen Black, Yu-Chieh Wang, L. James Lee, Mo Li*, Yubo Fan, Lingqian Chang*. On-chip Multiplexed Single-cell Patterning and Controllable Intracellular Delivery. Microsystems & Nanoengineering. 2020, 6: 2.
4. Zaizai Dong#, Xinying Xue#, Hailun Liang*, Jingjiao Guan*, Lingqian Chang*. DNA Nanomachines for Identifying Cancer Biomarkers in Body Fluids and Cells. Analytical Chemistry. 2021, 93(4): 1855-1865.
5. Zaizai Dong#, Yu Wang#, Dedong Yin, Xinxin Hang, Lei Pu, Jianfu Zhang, Jia Geng*, Lingqian Chang*. Advanced Techniques for Gene Heterogeneity Research: Single-cell Sequencing and On-chip Gene Analysis Systems. VIEW. 2022, 3: 20210011.
6. Zaizai Dong#, Chuanhao Tang#, Zhen Zhang, Wei Zhou, Rong Zhao, Lina Wang, Jiachao Xu, Yayun Wu, Jiang Wu, Xing Zhang, Li Xu, Libo Zhao*, Xiaohong Fang*. Simultaneous Detection of Exosomal Membrane Protein and RNA by Highly Sensitive Aptamer Assisted Multiplex-PCR. ACS Applied Bio Materials. 2020, 3(5): 2560-2567.
7. Zaizai Dong, Lingqian Chang*. Recent Electroporation-based Systems for Intracellular Molecule Delivery. Nanotechnology and Precision Engineering. 2021, 4: 045001.
8. Xinxin Hang#, Shiqi He#, Zaizai Dong#, Yun Li, Zheng Huang, Yanruo Zhang, Hong Sun, Long Lin, Hu Li, Yang Wang, Bing Liu, Nan Wu, Tianling Ren, Yubo Fan, Jizhong Lou, Ruiguo Yang, Lan Jiang*, Lingqian Chang*. High-throughput DNA Tensioner Platform for Interrogating Mechanical Heterogeneity of Single Living Cell. Small. 2022, 2106196.
9. Hong Sun#, Zaizai Dong#, *, Yusen Wang, Dedong Yin, Yang Wang, Lingqian Chang*. Companion-Probe & Race Platform for Interrogating Nuclear Proteins and Migration of Living Cells. Biosensors and Bioelectronics. 2022, 210, 114281.
10. Yang Wang#, Huiren Xu#, Zaizai Dong#, Zhiying Wang, Zhugen Yang, Xinge Yu, Lingqian Chang*. Micro/Nano Biomedical Devices for Point-of-Care Diagnosis of Infectious Respiratory Diseases. Medicine in Novel Technology and Devices. 2022, 14, 100116.
11. Long Lin, Yuqiong Wang, Minkun Cai, Xinran Jiang, Yongyan Hu, Zaizai Dong, Dedong Yin, Yilin Liu, Shaohua Yang, Zhiguang Liu, Jian Zhuang*, Ye Xu, Chuanfei Guo*, Lingqian Chang*. Multi-microchannel Microneedle Microporation Platform for Enhanced Intracellular Drug Delivery. Advanced Functional Materials. 2021, 2109187.
12. Yan Sheng#, Zena Huang#, Tenghua Zhang#, Feiyang Qian, Yuqing Zhu, Zaizai Dong, Qingyang Zhang, Qi Lei, Fanhui Kong, Yuqiong Wang, Maddie Walden, Stefan Wuttke, Lingqian Chang*, Wei Zhu*, Jiaming Hu*. Living Cell Nanoporation and Exosomal RNA Analysis Platform for Real-Time Assessment of Cellular Therapies. Journal of the American Chemical Society. 2022.
13. Yang Wang, Hong Sun, Qingyang Zhang, Gaolian Xu, Zhiying Wang, Zaizai Dong, Wenhui Chen, Xiaoxiao Yang, Anbang Qiao, Yubo Fan, Xinxia Cai, Lingqian Chang, Bo Wei. A Multiplexed Electrochemical Quantitative Polymerase Chain Reaction Platform for Single-base Mutation Analysis. Biosensors and Bioelectronics. 2022, 214:114496.
14. Wei Zhou, Guogui Sun, Zhen Zhang, Libo Zhao, Li Xu, Hongyu Yuan, Shumu Li, Zaizai Dong, Yongmei Song*, Xiaohong Fang*. Proteasome-Independent Protein Knockdown by Small-Molecule Inhibitor for the Undruggable Lung Adenocarcinoma. Journal of the American Chemical Society. 2019, 141(46): 18492-18499.
15. Xiao-Jun Tang, Yayun Wu, Rong Zhao, Xiaolong Kou, Zaizai Dong, Wei Zhou, Zhen Zhang, Weihong Tan, and Xiaohong Fang*. Photorelease of Pyridines Using a Metal-Free Photoremovable Protecting Group. Angewandte Chemie-International Edition. 2020, 59(42). 18386-18389.
16. Xinxin Hang, Shiqi He, Zaizai Dong, Grayson Minnick, Jordan Rosenbohm, Zhou Chen*, Ruiguo Yang*, Lingqian Chang*. Nanosensors for Single Cell Mechanical Interrogation. Biosensors & Bioelectronics. 2021, 179: 113086.
17. Yang Wang, Kaiju Li, Gaolian Xu, Chuan Chen, Guiqin Song, Zaizai Dong, Long Lin, Yu Wang, Zhiyong Xu, Mingxia Yu, Xinge Yu, Binwu Ying*, Yubo Fan*, Lingqian Chang*, Jia Geng*. Low-Cost and Scalable Platform with Multiplexed Microwell Array Biochip for Rapid Diagnosis of COVID-19. Research. 2021, 2813643.
18. Yayun Wu, Hefei Ruan, Rong Zhao, Zaizai Dong, Wenhui Li, Xiaojun Tang, Jinghe Yuan, Xiaohong Fang*. Ultrastable Fluorescent Polymer Dots for Stimulated Emission Depletion Bioimaging. Advanced Optical Materials. 2018, 6(19): 1800333.
19. Zhen Zhang*, Chuanhao Tang, Libo Zhao, Li Xu, Wei Zhou, Zaizai Dong, Yuqing Yang, Qiqi Xie, Xiaohong Fang*. Aptamer-Based Fluorescence Polarization Assay for Separation-Free Exosome Quantification. Nanoscale. 2019, 11(20): 10106-10113.
20. Ping-An Chen, Jin Guo, Mehdi Nouri, Quanyang Tao, Zhiwei Li, Qianyuan Li, Lulu Du, Huajie Chen, Zaizai Dong, Lingqian Chang*, Yuan Liu, Lei Liao, Yuanyuan Hu*. Microfluidic Solution-processed Organic and Perovskite Nanowires Fabricated for Field-effect Transistors and Photodetectors. Journal of Materials Chemistry C. 2020, 8(7): 2353-2362.
21. Yayun Wu, Hefei Ruan, Zaizai Dong, Rong Zhao, Jianqiang Yu, Xiaojun Tang, Xiaolong Kou, Xing Zhang, Manchen Wu, Fang Luo, Jinghe Yuan*, Xiaohong Fang*. Fluorescent Polymer Dot-Based Multicolor Stimulated Emission Depletion Nanoscopy with a Single Laser Beam Pair for Cellular Tracking. Analytical Chemistry. 2020, 92(17), 12088-12096.
22. Qianmin Zhang#, Xiaojuan Wei#, Yongli Ji#, Li Yin, Zaizai Dong, Feng Chen*, Mingqiang Zhong, Jian Shen, Zhenjie Liu*, Lingqian Chang*. Adjustable and Ultrafast Light-cured Hyaluronic Acid Hydrogel: Promoting Biocompatibility and Cell Growth. Journal of Materials Chemistry B. 2020, 8(25): 5441-5450.
Book Chapter
Zaizai Dong#, Tongren Yang#, Han Wu, Justin Brooks, Ruiguo Yang, Yuanyu Huang, Lingqian Chang. Chapter 5: Advanced microfluidic devices for cell electroporation and manipulation. MICRO AND NANO SYSTEMS FOR BIOPHYSICAL STUDIES OF CELLS AND SMALL ORGANISMS. Elsevier. 2021.
Patent
1. 常凌乾；董再再，基于单细胞阵列的纳米电穿孔装置及其应用，CN112226365A
2. 常凌乾；董再再; 孙宏，一种新型活细胞核内蛋白检测方法与装置，202210384917.0
3. 常凌乾；董再再; 万凤奇，一种活细胞内增强子活性鉴定方法与装置，202210492754.8
4. 方晓红；董再再；赵立波；张振；周卫；徐丽，一种基于核酸适体免疫PCR共同表征外泌体膜标志物和RNA的方法，ZL201911011894.3
5. 方晓红；董再再；赵立波；张振；徐丽；周卫，一种耐药异质性循环肿瘤细胞捕获与基因分析的试剂、装置和方法，ZL201811180288.X
6. 方晓红；张振；董再再；徐丽，核酸适体酶联检测试剂盒和制备方法及其应用，ZL201810677985.X
7. 方晓红；张振；赵子龙；徐丽；董再再；赵立波，一种亲和丙型病毒性肝炎核心蛋白的核酸适体及其应用，ZL201410219472.6
8. 方晓红；张振；赵子龙；徐丽；董再再；赵立波，亲和丙型病毒性肝炎核心抗原的核酸适体及其应用，ZL201410482700.9
