赵心彬 准聘副教授/博士生导师
北京航空航天大学 医学科学与工程学院/生物医学工程高精尖创新中心
北航教师主页：https://shi.buaa.edu.cn/b18134/zh_CN/index.htm
电子邮箱: jorbin368@buaa.edu.cn / jorbin368@126.com
【教育背景】
2015.9-2018.10 清华大学 | 药学院 | 博士学位
2010.9-2013.6 第二军医大学 | 长征医院 | 硕士学位
2006.9-2010.6 江苏大学 | 药学院 | 学士学位
【工作经历】
2018.11-2021.12 北京航空航天大学 | 生物与医学工程学院 | 卓百博士后
2013.7-2015.8 清华大学 | 医学院 | 科研助理
【研究领域】
材料、生物、医学交叉等多学科交叉
细胞外基质材料对干细胞分化和保持干性的研究
肿瘤细胞迁移浸润过程中的生物力学机制
肿瘤细胞微环境中巨噬细胞极化的研究
【代表性科研项目】
1. 国家自然科学基金青年基金，11902020，2020.01-2022.12，20万元，在研，主持。
2. 中国博士后科学基金面上资助，2019M660390, 2019.05-2021.12，8万元，结题，主持。
3. 北航青年拔尖人才计划，2022.6-2026.12，50万元，在研，主持。
4. 国家自然科学基金面上项目，81470839，2015/01-2018/12，120万元，已结题，参与。
【代表性论著】
(1) Xin-Bin Zhao, Yun-Ping Chen, Min Tan, ..., Xi-Qiao Feng, Jing Du,* and Yu-Bo Fan*. Extracellular Matrix Stiffness Regulates DNA Methylation by PKCα-Dependent Nuclear Transport of DNMT3L. (2021). Advanced Healthcare Materials. 2100821.
(2) Xinbin Zhao, Yuecheng Ding, Jing Du, Yubo Fan. 2020 update on human coronaviruses: One health, one world. (2020). Medicine in Novel Technology and Devices. 8,100043.
(3) Liangliang Ji#, Xinbin Zhao#, ..., Ligong Chen* and Xiaoyu Hu*. Slc6a8-mediated creatine uptake and accumulation reprogram macrophage polarization via regulating cytokine responses. (2019). Immunity. 51, 272-284.
(4) Yunan Luo#, Xinbin Zhao#, Jingtian Zhou#, ..., Ligong Chen* and Jianyang Zeng*. (2017). A network integration approach for drug-target interaction prediction and computational drug repositioning from heterogeneous information. Nature Communications, 8, 573-586.
(5) Xinbin Zhao, ..., Siegenthaler Julie A and Ligong Chen*. (2017). Tenofovir and adefovir down-regulate mitochondrial chaperone TRAP1 and succinate dehydrogenase subunit B to metabolically reprogram glucose metabolism and induce nephrotoxicity. Scientific Reports, 7, 46344-46359.
(6) Xinbin Zhao, ..., Fuming Shen, Xiao Tao*. (2014). Simvastatin attenuates radiation-induced tissue damage in mice. Journal of Radiation Research. 5,257-264.
(7) Wenhua Kuang, ..., Xinbin Zhao, ..., Ligong Chen. SLC22A14 is a mitochondrial riboflavin transporter required for sperm oxidative phosphorylation and male fertility. (2020). Cell Reports. 35, 109025.
(8) Lili Cheng, Mengmeng Ge, ..., Xinbin Zhao, ..., Ligong Chen*. Zoledronate dysregulates fatty acid metabolism in renal tubular epithelial cells to induce nephrotoxicity. (2018). Archives Toxicology. 92, 469-485.
(9) Hong Yang, Fei Huang, Yulong Tao, Xinbin Zhao, Lina Liao, Xia Tao. Simvastatin ameliorates ionizing radiation-induced apoptosis in the thymus by activating the AKT/sirtuin 1 pathway in mice. (2017). International Journal of Molecular Medicine. 40: 762-770, 2017
(10) Ung Peter Man-Un, Wenxin Song, Lili Cheng, Xinbin Zhao, Hailin Hu, Ligong Chen* and Schlessinger Avner*. Inhibitor Discovery for the Human GLUT1 from Homology Modeling and Virtual Screening.(2016). ACS Chemical Biology. 11, 1908−1916.
(11) Haiping Tang, ..., Ligong Chen, Xinbin Zhao, Haiteng Deng, Xiaohui Liu. Establishment of local searching methods for orbitrap-based high throughput metabolomics analysis. (2016). Talanta156-157,163-171.
(12) Hong Yang, Fei Huang, Min Ni, Xinbin Zhao, Ya-Ping Deng, Jia-Wen Yu, Guo-Jun Jiang and Xia Tao. Cognitive Function is Impaired by Obesity and Alleviated by Lorcaserin Treatment in Mice. (2015). CNS. Neuroscience & Therapeutics. 21, 472-474
(13) Jikuai Chen, Zhangpeng Li, Yunzi Liu, Ting Zhao, Xinbin Zhao, Min Ni, Guojun Jiang * and Fuming Shen *. Activation of Alpha 7 Nicotinic Acetylcholine Receptor Protects Mice from Radiation-Induced Intestinal Injury and Mortality. (2014). Radiation Research. 181, 666-671.
【招生】
欢迎具有生命科学、医学、生物工程、肿瘤免疫学等相关背景的同学加入。如有意向，可直接电邮或电话联系。
