李长剑 助理教授、硕士生导师
医学科学与工程学院
北航教师个人主页：https://shi.buaa.edu.cn/lichangjian/zh_CN/index/194927/list/index.htm
电子邮箱：lichangjian@buaa.edu.cn
【教育背景】
2014-09至2019-06，中国科学院化学研究所，化学，博士
2010-09至2014-06，郑州大学，材料科学与工程，学士
【工作经历】
2021-12至今，北京航空航天大学，医学科学与工程学院，助理教授
2019-07至2021-12, 北京航空航天大学，博士后，导师: 田捷
【研究领域】
利用近红外荧光成像、磁粒子成像等新型光学、电磁学成像技术，结合人工智能新方法研发，开展肿瘤、心血管等重大疾病精准检测。涵盖成像系统研制、成像探针研发、成像算法开发、生物医学应用研究等方向。与北京大学人民医院、北京协和医院、中国医学科学院肿瘤医院等临床研究团队开展医工交叉深度合作，在肺癌、乳腺癌、结直肠癌等疾病精准影像方向开展系统性研究工作。
1. 近红外二区荧光手术导航研究
2. 磁粒子成像技术研究
3. 人工智能结合医学影像技术新方法研究
【代表性科研项目】
1. 科技部，国家重点研发计划“纳米科技”重点专项，2017YFA0205200，基于近红外纳米探针的肝癌分子影像及其手术导航技术研发，2017.07-2022.06，课题骨干
2. 国家自然科学基金委员会，国家重大科研仪器研制专项（部委推荐），62027901，基于磁纳米粒子非线性响应的活体动物三维融合成像设备，2021.01-2025.12，课题骨干
3. 中国博士后科学基金特别资助，2019TQ0018，近红外光学手术导航探针设计与应用，2019.07-2021.12，主持
4. 中央高校基本科研业务费专项资金资助，医工卓越创新计划基金，JKF-YG-22-B005，新型NIR-II荧光探针在肝癌手术导航中的应用研究，2022.07-2022.12，主持
5. 北京市自然科学基金，磁粒子成像/近红外二区荧光融合的多模态分子影像技术用于肺癌术中导航研究，2024.01-2025.12，主持
6. 北航“敢为行动”计划，JK2024-2-35-02，基于磁粒子成像技术的阿尔兹海默症早期诊断与干预策略研究，2024.11-2026.6，主持
7. 北京市自然科学基金联合重点，基于近红外分子探针的骨肉瘤精准外科与高效免疫协同治疗研究，2024.10-2027.09，子课题主持
8. 横向项目，和中消痞颗粒治疗胃癌前病变的随机对照临床研究，2024.09-2025.12，主持
9. 横向项目，结肠癌多模态成像探针研发和荧光成像研究，2025.05-2025.07，主持
10. 横向项目，ROS/TfR1双靶向心肌缺血再灌注损伤光磁多模态成像研究，2025.11-2026.02，主持
【代表性论著】
[1] Li Changjian#, Jiahui Mi#, Yueqi Wang#, Zeyu Zhang, Xiaoyong Guo, Jian Zhou*, Zhenhua Hu*, Jie Tian*. New and effective EGFR-targeted fluorescence imaging technology for intraoperative rapid determination of lung cancer in freshly isolated tissue. European Journal of Nuclear Medicine and Molecular Imaging, 2023, 50(2): 494-507.
[2] Jin Shangkun#, Li Changjian#, Jia Xiaohua#, Quan Jichuan, Guo Xiaoyong, Kong Wenzhi, Wang Yueqi, Wang Yuhan, Tian Jie*, Hu Zhenhua*, Tang Jianqiang*. A new EGFR and c-Met bispecific NIR-II fluorescent probe for visualising colorectal cancer and metastatic lymph nodes. eBioMedicine, 2025, 115: 105687.
[3] Li Chao#, Li Changjian#, Zhou Jian#, Wang Yueqi#, Wu Hainan, Xu Luzheng, Li Yifeng, Sui Xizhao, Jiang Guanchao, Li Yun, Hu Zhenhua*, Tian Jie*, Yang Fan*. Application of epithelial growth factor receptor-targeted magnetic resonance imaging and near-infrared-II dual-modal probe in lung cancer diagnosis and surgical resection. Molecular Pharmaceutics, 2025, 22, 3, 1198–1209.
[4] Li Qilong#, Li Changjian#, Wang Yueqi#, Li Miaomiao, Liang Zeyu, Wang Qiyue, Wang Bingzhe, Huang Canyu, Tian Jie*, Li Fangyuan*, Ling Daishun*. Bimagnetic Core/Shell Nanoprobes with Tunable Exchange Coupling for High Resolution and Sensitive Magnetic Particle Imaging. Angewandte Chemie International Edition, 2025, 137(6): e202418015.
[5] Zeng Fanwei#, Li Changjian#, Wang Han, Wang Yueqi, Ren Tingting, He Fangzhou, Jiang Jie, Xu Jiuhui, Wang Boyang, Wu Yifan, Yu Yiyang, Hu Zhenhua*, Tian Jie*, Wang Shidong*, Tang Xiaodong*. Intraoperative Resection Guidance and Rapid Pathological Diagnosis of Osteosarcoma using B7H3 Targeted Probe under NIR-II Fluorescence Imaging. Advanced Science, 2024: 2310167.
[6] Mi Jiahui#, Li Changjian#, Yang Feng#, Shi Xiaojing#, Zhang Zeyu, Guo Lishuang, Jiang Guanchao, Li Yun, Wang Jun, Yang Fan*, Hu Zhenhua*, Zhou Jian*. Comparative Study of Indocyanine Green Fluorescence Imaging in Lung Cancer with Near-infrared-I/II Windows. Annals of Surgical Oncology, 2024, 31:2451–2460.
[7] Yang Wenwen#, Wang Yueqi#, Fu Changgeng#, Li Changjian#, Feng Feng, Li Hongzheng, Tan Ling, Qu Hua, Hui Hui, Wang Jingjing*, Tian Jie*, Long Linzi*. Quantitative visualization of myocardial ischemia-reperfusion-induced cardiac lesions via ferroptosis magnetic particle imaging, Theranostics, 2024, 14(3): 1081-1097.
[8] Wang Kun#, Du Yang#, Zhang Zeyu#, He KunShan, Cheng Zhongquan, Yin Lin, Dong Di, Li Changjian, Li Wei, Hu Zhenhua, Zhang Chong, Hui Hui, Chi Chongwei, Tian Jie*. Fluorescence image-guided tumour surgery. Nature Reviews Bioengineering, 2023, 1(3): 161-179.
[9] Guo Xiaoyong#, Li Changjian#, Jia Xiaohua#, Qu Yawei#, Li Miaomiao, Cao Caiguang, Zhang Zeyu, Qu Qiaojun, Luo Shuangling, Tang Jianqiang*, Liu Haifeng*, Hu Zhenhua*, Tian Jie*. NIR-II fluorescence imaging-guided colorectal cancer surgery targeting CEACAM5 by a nanobody, eBioMedicine, 2023, 89: 104476.
[10] Wang Yueqi#, Li Changjian#, Zhuo Jiaming, Hui Hui*, Zhou Bing*, Tian Jie*. The Detection of Divalent iron and Reactive Oxygen Species during Ferroptosis with the use of a Dual-Reaction Turn-On fluorescent probe. Molecular Imaging and Biology, 2023, 25(2): 423-434.
[11] Wang Yueqi#, Li Changjian#, Zhang Xiaojie, Kang Xiaoxuan, Li Yaru, Zhang Wenyu, Chen Yan, Liu Yang, Wang Weigang*, Ge Maofa, Du Libo*. Exposure to PM2.5 aggravates Parkinson’s disease via inhibition of autophagy and mitophagy pathway. Toxicology. 2021; 456:152770.
[12] Wang Yueqi#, Li Changjian#, Du Libo*, Liu Yang*. A reactive oxygen species-responsive dendrimer with low cytotoxicity for efficient and targeted gene delivery. Chinese Chemical Letters. 2020; 31(1):275-80.
[13] Li Changjian, Wang Yueqi, Huang Saipeng, Zhang Xiaojie, Kang Xiaoxuan, Sun Yanchi, Hu Ziyuan, Han Lu, Du Libo*, Liu Yang*. A photostable fluorescent probe for long-time imagining of lysosome in cell and nematode. Talanta. 2018; 188: 316-24.
[14] Li Changjian, Wang Yueqi, Zhang Xiaojie, Guo Xueling, Kang Xiaoxuan, Du Libo*, Liu Yang*. Red fluorescent carbon dots with phenylboronic acid tags for quick detection of Fe(III) in PC12 cells. Journal of Colloid and Interface Science. 2018; 526:487-96.
【招生】
欢迎生物医学工程、智能医学工程、医学、人工智能、材料学、化学等相关专业背景的优秀学子加入研究组，开展近红外二区荧光成像、磁粒子成像等新型影像技术硬件开发、软件算法、以及预临床/临床应用研究。有意者可直接发送简历至邮箱：lichangjian@buaa.edu.cn。
